ArticleProceedings of the National Academy of Sciences of the United States of America2021
Reward-specific satiety affects subjective value signals in orbitofrontal cortex during multicomponent economic choice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 30 citations in OpenAlex.
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Is the Whole the Sum of its Parts? Neural Computation of Consumer Bundle Valuation in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.bioRxiv : the preprint server for biology · 2025Article
- Characterizing Brainstem GLP-1 Control of Sensory-Specific Satiety in Male and Female Rats Across the Estrous Cycle.Biological psychiatry · 2025Article
- Effects of reward type and previous social experience on cognitive testing outcomes of weaned dairy calves.Scientific reports · 2025Article
- Cross-species translational paradigms for assessing positive valence system as defined by the RDoC matrix.Journal of neurochemistry · 2025Review
- A Method for Evaluating Hunger and Thirst in Monkeys by Measuring Blood Ghrelin and Osmolality Levels.eNeuro · 2024Article
- Worth the Work? Monkeys Discount Rewards by a Subjective Adapting Effort Cost.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Dorsal raphe neurons signal integrated value during multi-attribute decision-making.bioRxiv : the preprint server for biology · 2023Article
- Preferences reveal separable valuation systems in prefrontal-limbic circuits.bioRxiv : the preprint server for biology · 2023Article
- Worth the work? Monkeys discount rewards by a subjective adapting effort cost.bioRxiv : the preprint server for biology · 2023Article
- Mesolimbic dopamine release conveys causal associations.Science (New York, N.Y.) · 2022Article
- Chemogenetic Disconnection between the Orbitofrontal Cortex and the Rostromedial Caudate Nucleus Disrupts Motivational Control of Goal-Directed Action.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
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3 authors at 1 institution in 1 country.
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Abstract
Sensitivity to satiety constitutes a basic requirement for neuronal coding of subjective reward value. Satiety from natural ongoing consumption affects reward functions in learning and approach behavior. More specifically, satiety reduces the subjective economic value of individual rewards during choice between options that typically contain multiple reward components. The unconfounded assessment of economic reward value requires tests at choice indifference between two options, which is difficult to achieve with sated rewards. By conceptualizing choices between options with multiple reward components ("bundles"), Revealed Preference Theory may offer a solution. Despite satiety, choices against an unaltered reference bundle may remain indifferent when the reduced value of a sated bundle reward is compensated by larger amounts of an unsated reward of the same bundle, and then the value loss of the sated reward is indicated by the amount of the added unsated reward. Here, we show psychophysically titrated choice indifference in monkeys between bundles of differently sated rewards. Neuronal chosen value signals in the orbitofrontal cortex (OFC) followed closely the subjective value change within recording periods of individual neurons. A neuronal classifier distinguishing the bundles and predicting choice substantiated the subjective value change. The choice between conventional single rewards confirmed the neuronal changes seen with two-reward bundles. Thus, reward-specific satiety reduces subjective reward value signals in OFC. With satiety being an important factor of subjective reward value, these results extend the notion of subjective economic reward value coding in OFC neurons.
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