Evidence map›Paper›PMID 34285053›Full record

ArticleGenome research2021

Sequence-based correction of barcode bias in massively parallel reporter assays.

Dongwon Lee, Ashish Kapoor, Changhee Lee, Michael Mudgett, Michael A Beer, Aravinda Chakravarti

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Dongwon LeeCenter for Human Genetics and Genomics, New York University School of Medicine, New York, New York 10016, USA.
Ashish KapoorInstitute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Changhee LeeDepartment of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Michael MudgettDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Michael A BeerDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Aravinda ChakravartiCenter for Human Genetics and Genomics, New York University School of Medicine, New York, New York 10016, USA.
Center for Human Genetics · USJohns Hopkins University · USHarvard University · USThe University of Texas Health Science Center · US

Funding

Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Genomics of blood pressure-induced target organ damageR01HL128782 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHAKRAVARTI, ARAVINDA · 2015 to 2018
$7.8M
GWAS TO GENE FUNCTION: NOS1AP AND OTHER QT INTERVAL GENESR01GM104469 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHAKRAVARTI, ARAVINDA · 2014 to 2017
$2.5M
NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL128782NIGMS NIH HHS R01 GM104469
6 · The paper itself

Abstract

Massively parallel reporter assays (MPRAs) are a high-throughput method for evaluating in vitro activities of thousands of candidate

Indexed as

Gene Expression RegulationRegulatory Sequences, Nucleic AcidBiasBiological AssayGenes, Reporter

Identifiers

PMID34285053
PMCPMC8415370
OpenAlexW3185496276

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.