Evidence map›Paper›PMID 34284676›Full record

ArticleLupus2021

Impact of the first wave of the COVID-19 pandemic on systemic lupus erythematosus patients: Results from a multi-center prospective cohort.

Shanthini Kasturi, Lori Lyn Price, Vasilissa Paushkin, Jane E Salmon, Timothy E McAlindon, Lisa A Mandl

Abstract readMulticenter Study
In one paragraph

Article in Lupus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shanthini KasturiDivision of Rheumatology, Allergy & Immunology/Department of Medicine, Tufts Medical Center, Boston, USA.ORCID https://orcid.org/0000-0001-8496-5595
Lori Lyn PriceInstitute of Clinical Research and Health Policy Studies, 1867Tufts Medical Center, Tufts Medical Center, Boston, USA.
Vasilissa PaushkinDivision of Rheumatology, Allergy & Immunology/Department of Medicine, Tufts Medical Center, Boston, USA.
Jane E SalmonDivision of Rheumatology/Department of Medicine, Hospital for Special Surgery and Weill Cornell Medicine, New York, USA.
Timothy E McAlindonDivision of Rheumatology, Allergy & Immunology/Department of Medicine, Tufts Medical Center, Boston, USA.
Lisa A MandlDivision of Rheumatology/Department of Medicine, Hospital for Special Surgery and Weill Cornell Medicine, New York, USA.

Funding

Tufts Clinical and Translational Science Institute (Pilot Supplement)UL1TR002544 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2018 to 2022
$50.2M
CTSA Institutional Mentored Career Development Program (KL2)KL2TR002545 · NCATS · TUFTS UNIVERSITY BOSTON · PI FREUND, KAREN · 2018 to 2022
$5.0M
NCATS NIH HHS KL2 TR002545NCATS NIH HHS UL1 TR002544
6 · The paper itself

Abstract

objectiveThe aim of this study was to evaluate the initial impact of the COVID-19 pandemic on individuals with systemic lupus erythematosus (SLE).

methodsPatients with SLE participating in a multi-center longitudinal cohort study in New York and Boston were invited to complete a supplemental web-based questionnaire in the summer of 2020. Participants completed standardized patient-reported outcome (PRO) measures and a combination of Likert scale and open-ended questions exploring the impact of the COVID-19 pandemic on their health and access to health care. Changes in PROs were evaluated with paired t-tests and frequencies of worsened symptoms were calculated. A thematic qualitative analysis was conducted on free text responses.

resultsOf 97 patients invited, 63 (65%) completed a supplemental questionnaire. Nearly 50% of respondents exhibited increases in anxiety (47.5%) and depression (48.3%) and over 40% scored worse in measures of pain interference, fatigue, and cognitive abilities. Respondents with pre-existing diagnoses of anxiety did not differ from other participants in PRO scores, but were more than three times as likely to report worsened health status. Patients denied difficulties accessing medications (85%) or medical care (84%) and over 50% participated in telehealth visits. Anxiety and increased health risks due to immunosuppression were recurring themes in free text responses.

conclusionsSLE patients experienced a significant physical and emotional toll in the initial months of the COVID-19 pandemic. Comprehensive patient-centered care, including monitoring and addressing anxiety and health-related quality of life, is critical to improving health outcomes in this population during the ongoing health crisis.

Indexed as

Quality of LifeAdultAgedAnxietyCOVID-19DepressionHumansLongitudinal StudiesLupus Erythematosus, SystemicMaleMiddle AgedPainPandemicsPatient Reported Outcome MeasuresProspective StudiesSARS-CoV-2anxietyCOVID-19patient reported outcomesSystemic lupus erythematosustelemedicine

Identifiers

PMID34284676
PMCPMC8560554

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.