ArticleNeurobiology of aging2021
Healthy dietary intake moderates the effects of age on brain iron concentration and working memory performance.
Article in Neurobiology of aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The association between the MIND diet and cognitive health in middle-aged and older adults: A systematic review.The journal of nutrition, health & aging · 2025Pooled it
- Ferroptotic neurodegeneration and diet: a narrative review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Associations between cognitive reserve, iron deposition in the basal ganglia, and cognitive function in mild cognitive impairment.Frontiers in psychology · 2026Article
- Exploring the links among brain iron accumulation, cognitive performance, and dietary intake in older adults: A longitudinal MRI study.Neurobiology of aging · 2025Article
- Healthy dietary intake diminishes the effect of cerebral small vessel disease on cognitive performance in older adults.Frontiers in neurology · 2025Article
- Change in transverse relaxation rates (RHuman brain mapping · 2025Article
- A Review of the Association Between Dietary Intake and Brain Iron Levels in Older Adults: Preliminary Findings and Future Directions.Nutrients · 2024Review
- Iron homeostasis in older adults: balancing nutritional requirements and health risks.The journal of nutrition, health & aging · 2024Review
- Review
- High cortical iron is associated with the disruption of white matter tracts supporting cognitive function in healthy older adults.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Peripheral and Central Iron Measures in Alcohol Use Disorder and Aging: A Quantitative Susceptibility Mapping Pilot Study.International journal of molecular sciences · 2023Article
- Metabolic profile-based subgroups can identify differences in brain volumes and brain iron deposition.Diabetes, obesity & metabolism · 2023Article
- Cognition and brain iron deposition in whole grey matter regions and hippocampal subfields.The European journal of neuroscience · 2022Article
- Article
- Ironsmith: An automated pipeline for QSM-based data analyses.NeuroImage · 2022Article
- Multi-compartment diffusion magnetic resonance imaging models link tract-related characteristics with working memory performance in healthy older adults.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Age-related brain iron accumulation is linked with oxidative stress, neurodegeneration and cognitive decline. Certain nutrients can reduce brain iron concentration in animal models, however, this association is not well established in humans. Moreover, it remains unknown if nutrition can moderate the effects of age on brain iron concentration and/or cognition. Here, we explored these issues in a sample of 73 healthy older adults (61-86 years old), while controlling for several factors such as age, gender, years of education, physical fitness and alcohol-intake. Quantitative susceptibility mapping was used for assessment of brain iron concentration and participants performed an N-Back paradigm to evaluate working memory performance. Nutritional-intake was assessed via a validated questionnaire. Nutrients were grouped into nutrition factors based on previous literature and factor analysis. One factor, comprised of vitamin E, lysine, DHA omega-3 and LA omega-6 PUFA, representing food groups such as nuts, healthy oils and fish, moderated the effects of age on both brain iron concentration and working memory performance, suggesting that these nutrients may slow the rate of brain iron accumulation and working memory declines in aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.