Evidence map›Paper›PMID 34284114›Full record

ArticleBrain, behavior, and immunity2021

Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury.

Andrew D Gaudet, Laura K Fonken, Monica T Ayala, Steven F Maier, Linda R Watkins

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. The Brain and Spinal Microvasculature in Normal Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Andrew D GaudetDepartment of Psychology, College of Liberal Arts, University of Texas at Austin, Austin, TX 78712, USA; Department of Neurology, Dell Medical School, University of Texas at Austin, Austin, TX 78712, USA; Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA; Department of Psychology and Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, UCB 603, Boulder, CO 80301, USA; Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, UCB 603, Boulder, CO 80301, USA. Electronic address: andrew.gaudet@utexas.edu.
Laura K FonkenInstitute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA; Division of Pharmacology and Toxicology, University of Texas at Austin, Austin, TX 78712, USA; Department of Psychology and Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, UCB 603, Boulder, CO 80301, USA; Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, UCB 603, Boulder, CO 80301, USA. Electronic address: laura.fonken@austin.utexas.edu.
Monica T AyalaDepartment of Psychology and Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, UCB 603, Boulder, CO 80301, USA; Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, UCB 603, Boulder, CO 80301, USA. Electronic address: mayala@s.idahocom.org.
Steven F MaierDepartment of Psychology and Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, UCB 603, Boulder, CO 80301, USA; Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, UCB 603, Boulder, CO 80301, USA. Electronic address: steve.maier@colorado.edu.
Linda R WatkinsDepartment of Psychology and Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, UCB 603, Boulder, CO 80301, USA; Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, UCB 603, Boulder, CO 80301, USA. Electronic address: linda.watkins@colorado.edu.
University of Colorado Boulder · USThe University of Texas at Austin · US

Funding

Targeting age-related neuroinflammation and postoperative cognitive decline: a microbial-based approachR01AG062716 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI FONKEN, LAURA K · 2020 to 2024
$2.4M
NIA NIH HHS R01 AG062716
6 · The paper itself

Abstract

Spinal cord injury (SCI) elicits chronic pain in 65% of individuals. In addition, SCI afflicts an increasing number of aged individuals, and those with SCI are predisposed to shorter lifespan. Our group previously identified that deletion of the microRNA miR-155 reduced neuroinflammation and locomotor deficits after SCI. Here, we hypothesized that aged mice would be more susceptible to pain symptoms and death soon after SCI, and that miR-155 deletion would reduce pain symptoms in adult and aged mice and improve survival. Adult (2 month-old) and aged (20 month-old) female wildtype (WT) and miR-155 knockout (KO) mice received T9 contusion SCI. Aged WT mice displayed reduced survival and increased autotomy - a symptom of spontaneous pain. In contrast, aged miR-155 KO mice after SCI were less susceptible to death or spontaneous pain. Evoked pain symptoms were tested using heat (Hargreaves test) and mechanical (von Frey) stimuli. At baseline, aged mice showed heightened heat sensitivity. After SCI, adult and aged WT and miR-155 KO mice all exhibited heat and mechanical hypersensitivity at all timepoints. miR-155 deletion in adult (but not aged) mice reduced mechanical hypersensitivity at 7 and 14 d post-SCI. Therefore, aging predisposes mice to SCI-elicited spontaneous pain and expedited mortality. miR-155 deletion in adult mice reduces evoked pain symptoms, and miR-155 deletion in aged mice reduces spontaneous pain and expedited mortality post-SCI. This study highlights the importance of studying geriatric models of SCI, and that inflammatory mediators such as miR-155 are promising targets after SCI for improving pain relief and longevity.

Indexed as

MicroRNAsNeuralgiaSpinal Cord InjuriesAgingAnimalsDisease Models, AnimalFemaleHyperalgesiaMiceMice, KnockoutSpinal CordMicroRNAsMirn155 microRNA, mouseAgingChronic painLongevityMechanical allodyniamicroRNANeuroinflammationNeuropathic painSpinal cord injuryThermal hyperalgesia

Identifiers

PMID34284114
PMCPMC8453092
OpenAlexW3183637964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.