Evidence map›Paper›PMID 34284042›Full record

ArticleNeuropharmacology2021

Sustained treatment with an α5 GABA A receptor negative allosteric modulator delays excitatory circuit development while maintaining GABAergic neurotransmission.

Jessica L Nuwer, Megan L Brady, Nadya V Povysheva, Amanda Coyne, Tija C Jacob

Open access · greenAbstract read
In one paragraph

Article in Neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. γ-Aminobutyric acid transporter and GABABrain communications · 2024
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jessica L NuwerDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Megan L BradyDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Nadya V PovyshevaDepartment of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.
Amanda CoyneDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Tija C JacobDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: tcj11@pitt.edu.
University of Pittsburgh · US

Funding

Training in the Neurobiology of Neurological DiseaseT32NS086749 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Omar El Gharbawie, REBECCA P SEAL · 2014 to 2026
$4.8M
NINDS NIH HHS T32 NS086749
6 · The paper itself

Abstract

α5 subunit GABA type A receptor (GABA

Indexed as

AnimalsDendritesExcitatory Postsynaptic PotentialsGABA AgentsGABA-A Receptor Antagonistsgamma-Aminobutyric AcidImidazolesRatsReceptors, GABA-AReceptors, N-Methyl-D-AspartateSynapsesSynaptic TransmissionGABA AgentsGABA-A Receptor AntagonistsGabra5 protein, ratgamma-Aminobutyric AcidImidazolesL 655,708NR2B NMDA receptorReceptors, GABA-AReceptors, N-Methyl-D-AspartateDendritic spinesExcitatoryGABA(A) receptorGluN2AGluN2BInhibitoryNMDA receptorPharmacologySynapseα5 subunit

Identifiers

PMID34284042
PMCPMC8514124
OpenAlexW3185061199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.