Evidence map›Paper›PMID 34283993›Full record

ArticleArchives of physical medicine and rehabilitation2021

Association of Lifetime TBI and Military Employment with Late Life ADL Functioning: A Population-Based Prospective Cohort Study.

Laura Tabio, Rod L Walker, Paul K Crane, Laura E Gibbons, Raj G Kumar, Melinda C Power, Amy S Kelley, Eric B Larson, Kristen Dams-O'Connor

Abstract read
In one paragraph

Article in Archives of physical medicine and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laura TabioDepartment of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: laura.tabio@mountsinai.org.
Rod L WalkerKaiser Permanente Washington Health Research Institute, Seattle, WA.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, WA.
Laura E GibbonsDepartment of Medicine, University of Washington, Seattle, WA.
Raj G KumarDepartment of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY.
Melinda C PowerDepartment of Epidemiology, George Washington University Milken Institute School of Public Health, Washington, DC.
Amy S KelleyDepartment of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Eric B LarsonKaiser Permanente Washington Health Research Institute, Seattle, WA.
Kristen Dams-O'ConnorDepartment of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.

Funding

Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI CHRISTOPHER DIRK KEENE · 2021 to 2026
$80.4M
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI BUCHWALD, DEDRA S · 1985 to 2019
$57.2M
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
Leveraging Existing Aging Research Networks to investigate TBI and AD/ADRD risk (LEARN TBI & AD)R01AG061028 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAMS-O'CONNOR, KRISTEN, MEZ, JESSE BENJAMIN · 2019 to 2023
$5.9M
Midcareer Investigator Award for Patient-Oriented Research in Dementia and Serious IllnessK24AG062785 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KELLEY, AMY STEVES · 2019 to 2022
$581k
NIA NIH HHS K24 AG062785NIA NIH HHS P50 AG005136NIA NIH HHS R01 AG061028NIA NIH HHS U01 AG006781NIA NIH HHS U19 AG066567
6 · The paper itself

Abstract

objectiveTo determine associations of traumatic brain injury (TBI) and military employment with activities of daily living (ADL) in late life.

designPopulation-based prospective cohort study with biennial follow-up and censoring at the time of dementia diagnosis.

settingCommunity-based integrated health care delivery system.

participantsParticipants (N=4953) were men (n=2066) and women (n=2887) aged ≥65 years who were dementia free.

interventionsNot applicable.

main outcome measuresADL difficulties at baseline and accumulation during follow-up.

resultsTBI with loss of consciousness (LOC) before the age of 40 years was associated with slightly higher ADL difficulty at baseline for women (rate ratio [RR], 1.44; 95% confidence interval [CI], 1.08-1.93; P=.01). For men, TBI with LOC at any age was associated with greater ADL difficulty at baseline (age <40y: RR, 1.58; 95% CI, 1.20-2.08; P=.001; age ≥40y: RR, 2.14; 95% CI, 1.24-3.68; P=.006). TBI with LOC was not associated with the rate of accumulation of ADL difficulties over time in men or women. There was no evidence of an association between military employment and either outcome, nor of an interaction between military employment and TBI with LOC. Findings were consistent across a variety of sensitivity analyses.

conclusionsFurther investigation into factors underlying greater late life functional impairment among survivors of TBI is warranted.

Indexed as

Activities of Daily LivingEmploymentMilitary PersonnelVeteransAdultAgedAged, 80 and overBrain Injuries, TraumaticCohort StudiesFemaleHumansMaleMiddle AgedProspective StudiesUnconsciousnessActivities of daily livingBrain injuries, traumaticMilitary personnelProspective cohort studiesRehabilitation

Identifiers

PMID34283993
PMCPMC11645840

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.