ArticleImmunity2021
Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation.
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Article in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 57 citations in OpenAlex.
- Oral Probenecid for Nonhospitalized Adults with Symptomatic Mild-to-Moderate COVID-19.Viruses · 2023Trial
- Pannexin 1 phosphorylation sites differentially modulate channel activity and physiological outcomes.bioRxiv : the preprint server for biology · 2026Article
- Inhibition of salt-inducible kinases reprograms T cells and antitumor immunity in ovarian cancer.Nature immunology · 2026Article
- Salt-inducible kinase 1 is a key gene in suppressing EVD68-induced asthma by modulating antiviral immunity.Genes & diseases · 2026Article
- Pannexins in the heart: cell-specific expression and contributions to disease.Cell and tissue research · 2026Review
- Pannexins in the vasculature.American journal of physiology. Heart and circulatory physiology · 2025Review
- Next Decade Research in Asthma: Broad Omics-Based Exploration Versus Targeted Airway Epithelium Studies.Journal of clinical medicine · 2025Review
- Pannexin channels in the kidney.American journal of physiology. Renal physiology · 2025Review
- Innate detection ofbioRxiv : the preprint server for biology · 2025Article
- The immunology of asthma.Nature immunology · 2025Review
- Proximal tubule pannexin 1 contributes to mitochondrial dysfunction and cell death during acute kidney injury.American journal of physiology. Renal physiology · 2025Article
- Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers.The Journal of general physiology · 2025Article
- Pannexin channels in inflammation and tumorigenesis.Frontiers in cell and developmental biology · 2025Review
- Pannexin-1 hemichannels promote experimental colitis inflammation in a CD4Frontiers in immunology · 2025Article
- The impact of Panx1 on inflammation, immunity, and cancer: a comprehensive review.Frontiers in medicine · 2025Review
- Channel plan: control of adaptive immune responses by pannexins.Trends in immunology · 2024Review
- The ATP-exporting channel Pannexin 1 promotes CD8iScience · 2024Article
- Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309.eLife · 2024Article
- The ATP-exporting channel Pannexin-1 promotes CD8bioRxiv : the preprint server for biology · 2024Article
- Regulatory T cell-mediated immunosuppression orchestrated by cancer: towards an immuno-genomic paradigm for precision medicine.Nature reviews. Clinical oncology · 2024Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 4 countries.
Christopher B MedinaCenter for Cell Clearance, University of Virginia, Charlottesville, VA 22908, USA; Departments of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.
Yu-Hsin ChiuDepartment of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA; Institute of Biotechnology and Department of Medical Science, National Tsing Hua University, Hsinchu, 30071, Taiwan.
Marta E StremskaDepartments of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.
Christopher D LucasCenter for Cell Clearance, University of Virginia, Charlottesville, VA 22908, USA.
Ivan PoonDepartment of Biochemistry and Genetics, La Trobe University, Melbourne, VIC 3083, Australia.
Kenneth S TungDepartments of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.
Michael R ElliottCenter for Cell Clearance, University of Virginia, Charlottesville, VA 22908, USA; Departments of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.
Bimal DesaiDepartment of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
Ulrike M LorenzDepartments of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.
Douglas A BaylissDepartment of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.
Kodi S RavichandranCenter for Cell Clearance, University of Virginia, Charlottesville, VA 22908, USA; Departments of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA; VIB/UGent Inflammation Research Centre and the Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium. Electronic address: ravi@virginia.edu.
University of Virginia · USCarter Center · USLa Trobe University · AU
Funding
Role of Pannexins in Vascular Smooth Muscle CellsP01HL120840 · NHLBI · UNIVERSITY OF VIRGINIA · PI BAYLISS, DOUGLAS A., RAVICHANDRAN, KODI S · 2014 to 2023
$24.0MTRAINING IN THE PHARMACOLOGICAL SCIENCEST32GM007055 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LYNCH, KEVIN R. · 1985 to 2022
$7.2MTRPM7 at the Crossroads of Tissue Homeostasis and inflammationR01GM108989 · NIGMS · UNIVERSITY OF VIRGINIA · PI DESAI, BIMAL N. · 2016 to 2024
$3.3MMechanisms regulating apoptotic cell clearance in health and diseaseR35GM122542 · NIGMS · WASHINGTON UNIVERSITY · PI RAVICHANDRAN, KODI S · 2017 to 2021
$2.3MSolute carrier proteins and metal ion-based signaling during efferocytosisR37AI159551 · NIAID · WASHINGTON UNIVERSITY · PI Kodi S Ravichandran · 2026 to 2026
$611kInducible and Reversible in vivo Protein Degradation (IRIP) - attempting a new approach for modulating immune responsesR21AI135455 · NIAID · UNIVERSITY OF VIRGINIA · PI LORENZ, ULRIKE · 2018 to 2019
$444kUnderstanding T cell susceptibility to regulatory T cell-mediated suppressionR21AI139967 · NIAID · UNIVERSITY OF VIRGINIA · PI LORENZ, ULRIKE · 2019 to 2020
$435kNHLBI NIH HHS P01 HL120840NIAID NIH HHS R21 AI135455NIAID NIH HHS R21 AI139967NIAID NIH HHS R37 AI159551NIGMS NIH HHS R01 GM108989NIGMS NIH HHS R35 GM122542NIGMS NIH HHS T32 GM007055Wellcome Trust 206566/Z/17/Z
Abstract
Allergic airway inflammation is driven by type-2 CD4
Indexed as
AnimalsAsthmaCell CommunicationCell LineCell ProliferationConnexinsDisease Models, AnimalHEK293 CellsHumansJurkat CellsMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsProtein Serine-Threonine KinasesRespiratory SystemConnexinsNerve Tissue ProteinsPanx1 protein, mouseProtein Serine-Threonine KinasesSik1 protein, mousePannexin 1, extracellular ATP, lung, asthma, airway inflammation, T regulatory cell, T effector cell, Salt-inducible kinase, CD4 T cell, adenosine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.