ArticlePloS one2021
Central retinal vascular trunk deviation in unilateral normal-tension glaucoma.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Inter-eye comparison of corneal stiffness parameters in primary open-angle glaucoma patients with unilateral damage.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Changes in Major Retinal Blood Vessel Position Outside the Optic Nerve Head in Glaucomatous Eyes.Journal of ophthalmic & vision research · 2025Article
- Association between eyeball asymmetry and offset of openings in optic nerve head canal assessed by posterior polar eyeball topography.Scientific reports · 2024Article
- Optic nerve head factors associated with initial central visual field defect in primary open-angle glaucoma.Scientific reports · 2024Article
- Offset of openings in optic nerve head canal at level of Bruch's membrane, anterior sclera, and lamina cribrosa.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate whether the position of the central retinal vascular trunk (CRVT), as a surrogate of lamina cribrosa (LC) offset, was associated with the presence of glaucoma in normal-tension glaucoma (NTG) patients.
methodsThe position of the CRVT was measured as the deviation from the center of the Bruch's membrane opening (BMO), as delineated by spectral-domain optical coherence tomography imaging. The offset index was calculated as the distance of the CRVT from the BMO center relative to that of the BMO margin. The angular deviation of CRVT was measured with the horizontal nasal midline as 0° and the superior location as a positive value. The offset index and angular deviation were compared between glaucoma and fellow control eyes within individuals.
resultsNTG eyes had higher baseline intraocular pressure (P = 0.001), a larger β-zone parapapillary atrophy area (P = 0.013), and a larger offset index (P<0.001). In a generalized linear mixed-effects model, larger offset index was the only risk factor of NTG diagnosis (OR = 31.625, P<0.001). A generalized estimating equation regression model revealed that the offset index was larger in the NTG eyes than in the control eyes for all ranges of axial length, while it was the smallest for the axial length of 23.4 mm (all P<0.001).
conclusionsThe offset index was larger in the unilateral NTG eyes, which fact is suggestive of the potential role of LC/BMO offset as a loco-regional susceptibility factor.
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