Evidence map›Paper›PMID 34283881›Full record

ArticlePloS one2021

Development of an HPTLC-based dynamic reference standard for the analysis of complex natural products using Jarrah honey as test sample.

Md Khairul Islam, Tomislav Sostaric, Lee Yong Lim, Katherine Hammer, Cornelia Locher

Abstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Md Khairul IslamCooperative Research Centre for Honey Bee Products Limited (CRC HBP), University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0002-9333-6536
Tomislav SostaricDivision of Pharmacy, School of Allied Health, University of Western Australia, Crawley, Western Australia, Australia.
Lee Yong LimDivision of Pharmacy, School of Allied Health, University of Western Australia, Crawley, Western Australia, Australia.
Katherine HammerCooperative Research Centre for Honey Bee Products Limited (CRC HBP), University of Western Australia, Perth, Western Australia, Australia.
Cornelia LocherCooperative Research Centre for Honey Bee Products Limited (CRC HBP), University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0001-8773-3036

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this paper, we describe a novel approach to the development of a reference standard for the quality control of complex natural products, which will assist in the assessment of their authenticity and purity. The proposed method provides a template for the selection of samples, which can be pooled to obtain a reference standard. A shortfall of such an approach is, however, that the pooled sample is static in nature and therefore unable to capture difference in processing conditions or natural variations triggered by geographical or climatic impacts over time. To address this, the paper also outlines the development of a dynamic reference standard, which allows for ongoing adjustments to future variations. The method employs High-Performance Thin Layer Chromatography (HPTLC) derived extract profiles processed by multivariate analysis. The development of the dynamic reference standard is illustrated using honey, a complex natural matrix, as an example.

Indexed as

Biological ProductsChromatography, High Pressure LiquidChromatography, Thin LayerHoneyMultivariate AnalysisQuality ControlReference StandardsBiological Products

Identifiers

PMID34283881
PMCPMC8291655

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.