ArticleJournal of the American Chemical Society2021
Interstrand Aminoacyl Transfer in a tRNA Acceptor Stem-Overhang Mimic.
Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Crystal structure of a tRNA acceptor-stem mimic at 1.94 Å resolution.Acta crystallographica. Section F, Structural biology communications · 2026Article
- Efficient Assembly of Functional RNA byJournal of the American Chemical Society · 2025Article
- Life's homochirality: Across a prebiotic network.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Synthesis of Nucleoside Derivatives by Biomimetic Ester Migration.Chembiochem : a European journal of chemical biology · 2025Article
- Stereoselectivity of Aminoacyl-RNA Loop-Closing Ligation.Journal of the American Chemical Society · 2025Article
- Autocatalytic symmetry breaking and chiral amplification in a feedback network combining amino acid synthesis and ligation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Permeability selection of biologically relevant membranes matches the stereochemistry of life on Earth.PLoS biology · 2025Article
- Selective Nonenzymatic Formation of Biologically Common RNA Hairpins.Angewandte Chemie (International ed. in English) · 2025Article
- RNA-directed peptide synthesis across a nicked loop.Nucleic acids research · 2024Article
- Prebiotic chiral transfer from self-aminoacylating ribozymes may favor either handedness.Nature communications · 2024Article
- The astrochemical evolutionary traits of phospholipid membrane homochirality.Nature reviews. Chemistry · 2024Review
- A potential role for RNA aminoacylation prior to its role in peptide synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The Origin of RNA and the Formose-Ribose-RNA Pathway.International journal of molecular sciences · 2024Review
- Second-Generation Chiral Amino Acid Derivatives Afford High Stereoselectivity and Stability in Aqueous RNA Acylation.The Journal of organic chemistry · 2024Article
- Initial Amino Acid:Codon Assignments and Strength of Codon:Anticodon Binding.Journal of the American Chemical Society · 2024Article
- Base Pairing Promoted the Self-Organization of Genetic Coding, Catalysis, and Free-Energy Transduction.Life (Basel, Switzerland) · 2024Review
- From the RNA-Peptide World: Prebiotic Reaction Conditions Compatible with Lipid Membranes for the Formation of Lipophilic Random Peptides in the Presence of Short Oligonucleotides, and More.Life (Basel, Switzerland) · 2024Article
- Stereoselective RNA reaction with chiral 2'-OH acylating agents.Chemical science · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Protein-catalyzed aminoacylation of the 3'-overhang of tRNA by an aminoacyl-adenylate could not have taken place prior to the advent of genetically coded peptide synthesis, and yet the latter process has an absolute requirement for aminoacyl-tRNA. There must therefore have been an earlier nonprotein-catalyzed means of generating aminoacyl-tRNA. Here, we demonstrate efficient interstrand aminoacyl transfer from an aminoacyl phosphate mixed anhydride at the 5'-terminus of a tRNA acceptor stem mimic to the 2',3'-diol terminus of a short 3'-overhang. With certain five-base 3'-overhangs, the transfer of an alanyl residue is highly stereoselective with the l-enantiomer being favored to the extent of ∼10:1 over the d-enantiomer and is much more efficient than the transfer of a glycyl residue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.