Evidence map›Paper›PMID 34283341›Full record

ArticleBreast cancer research and treatment2021

Intermuscular fat density as a novel prognostic factor in breast cancer patients treated with adjuvant chemotherapy.

Ye Won Jeon, Hyung Soon Park, Yousun Ko, Yu Sub Sung, Byoung Yong Shim, Young Jin Suh, Hyun A Kim

Abstract read
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In one paragraph

Article in Breast cancer research and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Muscle quality during cancer treatment and associations with health-related quality of life.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. The Influence of Muscle Morphology on Oncological Outcomes: A Review.Journal of frailty, sarcopenia and falls · 2025
    Review
  8. Review
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  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ye Won Jeon *Department of Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Hyung Soon Park *Division of Medical Oncology, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Yousun KoBiomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.
Yu Sub SungClinical Research Center, Asan Medical Center, Seoul, Korea.
Byoung Yong ShimDivision of Medical Oncology, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Young Jin SuhDepartment of Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Hyun A KimDepartment of Radiology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, #93, Jungbu-daero, Paldal-gu, Suwon-si, Gyenggi-Do, 16247, Republic of Korea. sy2923@hanmail.net.ORCID http://orcid.org/0000-0002-3809-2743

Funding

Catholic University of Korea the program year of 2020Korea Health Industry Development Institute HI18C1216National Research Foundation of Korea 2020R1C1C1013598
6 · The paper itself

Abstract

backgroundBody composition, including sarcopenia and fat parameters, has received much attention as a prognostic factor in breast cancer.

methodsA total of 479 breast cancer patients who underwent surgery and received adjuvant chemotherapy were enrolled in this study. Body composition, including the index and density of skeletal muscle, visceral fat, subcutaneous fat, and intermuscular fat calculated by CT scan, was used as a prognostic factor. The endpoints were breast cancer-specific survival (BCSS) and overall survival (OS).

resultsThe number of patients with stages I, II, and III was 146 (30.5%), 237 (49.5%), and 96 (20%), respectively. Sarcopenia and muscle density were not significant prognostic factors for BCSS and OS. A high visceral fat index (VFI) was an independent prognostic factor for BCSS (HR, 2.55; 95% CI 1.10-5.95, p = 0.03) and OS (HR 2.55, 95% CI 1.26-5.16, p = 0.01). In addition, high intermuscular fat density (IMFD) was also a significant prognostic factor for BCSS (HR, 2.95; 95% CI 1.34-6.46, p = 0.007) and OS (HR 2.28, 95% CI 1.22-4.26, p = 0.01) in multivariate analysis.

conclusionVFI and IMFD were significant prognostic factors for BCSS and OS in breast cancer patients treated with adjuvant chemotherapy.

Indexed as

Breast NeoplasmsSarcopeniaBody CompositionChemotherapy, AdjuvantFemaleHumansPrognosisBreast cancerChemotherapyFat densitySurvivalVisceral obesity

Identifiers

PMID34283341

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.