Evidence map›Paper›PMID 34283320›Full record

ArticleEJNMMI physics2021

Characterization of point-spread function specification error on Geometric Transfer Matrix partial volume correction in [

Charles M Laymon, Davneet S Minhas, Sarah K Royse, Howard J Aizenstein, Ann D Cohen, Dana L Tudorascu, William E Klunk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Charles M LaymonDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA. cml14@pitt.edu.ORCID http://orcid.org/0000-0002-5966-7219
Davneet S MinhasDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
Sarah K RoyseDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
Howard J AizensteinDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Ann D CohenDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Dana L TudorascuDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
William E KlunkDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Vascular Moderators of the Impact of Alzheimer's Pathology in the Young-OldP01AG025204 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWARD J AIZENSTEIN, Ann D. Cohen · 2005 to 2026
$56.5M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 1985 to 2019
$43.0M
Research Education ComponentP30AG066468 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI C. Elizabeth Shaaban · 2020 to 2026
$29.4M
Roles of Gray Matter Brain Aging and Small Vessel Disease in AD PathophysiologyRF1AG025516 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENSTEIN, HOWARD J, VILLEMAGNE, VICTOR LUIS · 2014 to 2021
$9.0M
Role of midlife cardiovascular disease on Alzheimer’s Pathology and cerebrovascular reactivity in the young-old.R01AG052446 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COHEN, ANN D. · 2016 to 2020
$3.7M
Alzheimer neuroimaging-biomarkers in pre-clinical cognitive decline from a population-based studyR01AG052521 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SNITZ, BETH · 2016 to 2020
$3.3M
NIA NIH HHS P01AG025204NIA NIH HHS P01AG025204-13SNIA NIH HHS P30 AG066468NIA NIH HHS P50 AG005133NIA NIH HHS P50AG005133NIA NIH HHS R01AG052446NIA NIH HHS R01 AG052521NIA NIH HHS R01AG052521NIA NIH HHS RF1AG025516
6 · The paper itself

Abstract

purposePartial-volume correction (PVC) using the Geometric Transfer Matrix (GTM) method is used in positron emission tomography (PET) to compensate for the effects of spatial resolution on quantitation. We evaluate the effect of misspecification of scanner point-spread function (PSF) on GTM results in amyloid imaging, including the effect on amyloid status classification (positive or negative).

methodsTwenty-nine subjects with Pittsburgh Compound B ([

resultsErrors in specification of w on the order of 1 mm (3D) mainly produce only modest errors of up to a few percent. An exception was the anterior ventral striatum in which fractional errors of up to 0.29 per millimeter (3D) of error in w were observed.

conclusionWhile this study does not address all the issues regarding the quantitative strengths and weakness of GTM PVC, we find that with reasonable caution, the unavoidable inaccuracies associated with PSF specification do not preclude its use in amyloid quantitation.

Indexed as

BrainEvaluation and performanceNuclear imagingPartial volume effect correctionPositron emission tomographyQuantification and estimation

Identifiers

PMID34283320
PMCPMC8292473

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.