Evidence map›Paper›PMID 34283312›Full record

ArticleAmino acids2021

β-Methylamino-L-alanine-induced protein aggregation in vitro and protection by L-serine.

Adam W Quinn, Connor R Phillips, Jake P Violi, Joel R Steele, Michael S Johnson, Mika T Westerhausen, Kenneth J Rodgers

Abstract read
PubMed Publisher
In one paragraph

Article in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Adam W QuinnNeurotoxin Research Group, School of Life Sciences, University of Technology Syd, ney, Faculty of Science, Building 4, Level 7, room 329. Thomas Street, Sydney, NSW, 2007, Australia.
Connor R PhillipsNeurotoxin Research Group, School of Life Sciences, University of Technology Syd, ney, Faculty of Science, Building 4, Level 7, room 329. Thomas Street, Sydney, NSW, 2007, Australia.
Jake P VioliNeurotoxin Research Group, School of Life Sciences, University of Technology Syd, ney, Faculty of Science, Building 4, Level 7, room 329. Thomas Street, Sydney, NSW, 2007, Australia.
Joel R SteeleNeurotoxin Research Group, School of Life Sciences, University of Technology Syd, ney, Faculty of Science, Building 4, Level 7, room 329. Thomas Street, Sydney, NSW, 2007, Australia.
Michael S JohnsonNeurotoxin Research Group, School of Life Sciences, University of Technology Syd, ney, Faculty of Science, Building 4, Level 7, room 329. Thomas Street, Sydney, NSW, 2007, Australia.
Mika T WesterhausenNeurotoxin Research Group, School of Life Sciences, University of Technology Syd, ney, Faculty of Science, Building 4, Level 7, room 329. Thomas Street, Sydney, NSW, 2007, Australia.
Kenneth J RodgersNeurotoxin Research Group, School of Life Sciences, University of Technology Syd, ney, Faculty of Science, Building 4, Level 7, room 329. Thomas Street, Sydney, NSW, 2007, Australia. Kenneth.Rodgers@uts.edu.au.ORCID http://orcid.org/0000-0002-3627-9651

Funding

Motor Neurone Disease Australia PRO-15-0352
6 · The paper itself

Abstract

The cyanobacterial non-protein amino acid α-amino-β-methylaminopropionic acid, more commonly known as BMAA, was first discovered in the seeds of the ancient gymnosperm Cycad circinalis (now Cycas micronesica Hill). BMAA was linked to the high incidence of neurological disorders on the island of Guam first reported in the 1950s. BMAA still attracts interest as a possible causative factor in amyotrophic lateral sclerosis (ALS) following the identification of ALS disease clusters associated with living in proximity to lakes with regular cyanobacterial blooms. Since its discovery, BMAA toxicity has been the subject of many in vivo and in vitro studies. A number of mechanisms of toxicity have been proposed including an agonist effect at glutamate receptors, competition with cysteine for transport system x

Indexed as

Chaperone-Mediated AutophagyAmino Acids, DiaminoAntioxidantsCell DifferentiationCyanobacteria ToxinsExcitatory Amino Acid AgonistsHumansLysosomal-Associated Membrane Protein 2NeuroblastomaOxidative StressProteasome Endopeptidase ComplexProtein AggregatesSerineTumor Cells, CulturedUbiquitinAmino Acids, DiaminoAntioxidantsbeta-N-methylamino-L-alanineCyanobacteria ToxinsExcitatory Amino Acid AgonistsLAMP2 protein, humanLysosomal-Associated Membrane Protein 2Proteasome Endopeptidase ComplexProtein AggregatesSerineUbiquitinBMAALamp2aL-serineProtein aggregationUbiquitin

Identifiers

PMID34283312

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.