Evidence map›Paper›PMID 34283289›Full record

ArticleDysphagia2022

The Dosimetric Outcome of a Rotational Planning Target Volume in Patients With Oropharyngeal Cancers.

Mona Arbab, Gregory Bartlett, Benjamin Dawson, Jeffrey Ge, Mark Langer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dysphagia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mona ArbabDepartment of Radiation Oncology, Indiana University, 535 Barnhill Drive, RT041, Indianapolis, IN, 46202, USA. marbab@iu.edu.ORCID http://orcid.org/0000-0002-5770-4768
Gregory BartlettDepartment of Radiation Oncology, Indiana University, 535 Barnhill Drive, RT041, Indianapolis, IN, 46202, USA.
Benjamin DawsonDepartment of Radiation Oncology, Indiana University, 535 Barnhill Drive, RT041, Indianapolis, IN, 46202, USA.
Jeffrey GeDepartment of Mechanical Engineering, Stony Brook University, Stony Brook, NY, USA.
Mark LangerDepartment of Radiation Oncology, Indiana University, 535 Barnhill Drive, RT041, Indianapolis, IN, 46202, USA.
Indiana University – Purdue University Indianapolis · USStony Brook University · US

Funding

A Dual Quaternion Based Method for Estimating PTV Margins in Intensity-Modulated RadiotherapyR03CA249545 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI GE, QIAODE, LANGER, MARK P · 2020 to 2021
$174k
NCI NIH HHS R03 CA249545
6 · The paper itself

Abstract

An isotropic expanded Planning Target Volume (PTV) neglects patient's off-axis rotation. This study designs a rotational PTV that is used instead of the standard 3-mm Clinical Target Volume (CTV) expanded PTV in oropharyngeal cancers with the goal to reduce pharyngeal constrictor muscle (PCM) mean dose. 10 patients were retrospectively evaluated. For off-axis rotation, the image was rotated around the longitudinal axis (cervical spinal canal) ± 5 degrees. These new CTVs were combined to form the rotational PTV. The standard and rotational treatment plans were designed with the goal to keep the superior and middle PCM-CTV70 mean dose to less than 50 Gy. There were a 355 cGy reduction in the superior PCM mean dose (form 5332 to 4977 cGy) and a 506 cGy reduction in middle PCM mean dose (from 4185 to 3679 cGy). 60% of patients may have at least a 20% reduction in dysphagia probability based on a Normal Tissue Complication Probability (NTCP) formula. The superior and middle PCM mean dose were reduced to less than 50 Gy in 40 and 20% of cases. There was an association between superior PCM mean dose and overlap volume of PTV70 and superior PCM in both standard (r = 0.92, p = 0.001) and rotational (r = 0.84, p = 0.002) plans. This association was present for middle PCM and PTV70 (r = 0.52, p = 0.02 and r = 0.62, p = 0.006). Rotational PTV can lower the mean dose to superior and middle PCMs, ultimately leading to lower dysphagia rates.

Indexed as

Deglutition DisordersOropharyngeal NeoplasmsRadiotherapy, Intensity-ModulatedHumansRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRetrospective StudiesDeglutitionDeglutition disordersDysphagiaIMRTOropharyngeal cancerPharyngeal constrictor muscleRadiation

Identifiers

PMID34283289
PMCPMC11079995
OpenAlexW3184784240

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.