ArticleMicroscopy (Oxford, England)2021
Miniature microscopes for manipulating and recording in vivo brain activity.
Article in Microscopy (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed.
- Evaluating linear model frameworks for directed predictive influence estimation from hypothalamic calcium imaging.Journal of neuroscience methods · 2026Article
- Functional imaging of nine distinct neuronal populations under a miniscope in freely behaving animals.eLife · 2026Article
- Integrating Optics and Parametrically-Resonant Micro-Scanner Design for Large Working Distance Implantable Microscopy.IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division · 2025Article
- Disentangling the Neural Circuits of Arousal and Anxiety-Like Behavior.Current topics in behavioral neurosciences · 2025Review
- Population imaging of internal state circuits relevant to psychiatric disease: a review.Neurophotonics · 2025Review
- Calcium Signalling in Neurological Disorders, with Insights from Miniature Fluorescence Microscopy.Cells · 2024Review
- Egocentric neural representation of geometric vertex in the retrosplenial cortex.Nature communications · 2024Article
- Article
- Imaging distinct neuronal populations with a dual channel miniscope.Frontiers in neuroscience · 2024Article
- Review
- Dual-color miniscope imaging of microvessels and neuronal activity in the hippocampus CA1 region of freely moving mice following alcohol administration.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Astrocyte-specific CaBiochemistry and cell biology = Biochimie et biologie cellulaire · 2023Review
- 110 μm thin endo-microscope for deep-brain in vivo observations of neuronal connectivity, activity and blood flow dynamics.Nature communications · 2023Article
- Modern Microscopic Approaches to Astrocytes.International journal of molecular sciences · 2023Review
- GRIN lens applications for studying neurobiology of substance use disorder.Addiction neuroscience · 2022Article
- A miniature fluorescence microscope for multi-plane imaging.Scientific reports · 2022Article
- Early Changes in Striatal Activity and Motor Kinematics in a Huntington's Disease Mouse Model.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Cranial and Spinal Window Preparation forExperimental neurobiology · 2022Review
- In vivo imaging of the GnRH pulse generator reveals a temporal order of neuronal activation and synchronization during each pulse.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dissociable effects of oxycodone on behavior, calcium transient activity, and excitability of dorsolateral striatal neurons.Frontiers in neural circuits · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we describe the development and application of miniature integrated microscopes (miniscopes) paired with microendoscopes that allow for the visualization and manipulation of neural circuits in superficial and subcortical brain regions in freely behaving animals. Over the past decade the miniscope platform has expanded to include simultaneous optogenetic capabilities, electrically-tunable lenses that enable multi-plane imaging, color-corrected optics, and an integrated data acquisition platform that streamlines multimodal experiments. Miniscopes have given researchers an unprecedented ability to monitor hundreds to thousands of genetically-defined neurons from weeks to months in both healthy and diseased animal brains. Sophisticated algorithms that take advantage of constrained matrix factorization allow for background estimation and reliable cell identification, greatly improving the reliability and scalability of source extraction for large imaging datasets. Data generated from miniscopes have empowered researchers to investigate the neural circuit underpinnings of a wide array of behaviors that cannot be studied under head-fixed conditions, such as sleep, reward seeking, learning and memory, social behaviors, and feeding. Importantly, the miniscope has broadened our understanding of how neural circuits can go awry in animal models of progressive neurological disorders, such as Parkinson's disease. Continued miniscope development, including the ability to record from multiple populations of cells simultaneously, along with continued multimodal integration of techniques such as electrophysiology, will allow for deeper understanding into the neural circuits that underlie complex and naturalistic behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.