Evidence map›Paper›PMID 34283079›Full record

ArticleCancers2021

Combined Assessment of Preoperative Frailty and Sarcopenia Allows the Prediction of Overall Survival in Patients with Lung Cancer (NSCLC) and Surgically Treated Brain Metastasis.

Inja Ilic, Anton Faron, Muriel Heimann, Anna-Laura Potthoff, Niklas Schäfer, Christian Bode, Valeri Borger, Lars Eichhorn, Frank A Giordano, Erdem Güresir and 9 more

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Long-term survival in patients with brain metastases-clinical characterization of a rare scenario.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Inja IlicDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.
Anton FaronDepartment of Radiology, University Hospital Bonn, 53127 Bonn, Germany.
Muriel HeimannDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.
Anna-Laura PotthoffDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.
Niklas SchäferDivision of Clinical Neuro-Oncology, Department of Neurology, University Hospital Bonn, 53127 Bonn, Germany.
Christian BodeDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-0830-870X
Valeri BorgerDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-5905-4121
Lars EichhornDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-9769-0639
Frank A GiordanoDepartment of Radiation Oncology, University Hospital Bonn, 53127 Bonn, Germany.
Erdem GüresirDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0001-8319-0847
Andreas H JacobsDepartment of Geriatric Medicine and Neurology, Johanniter Hospital Bonn, 53113 Bonn, Germany.
Yon-Dschun KoDepartment of Oncology and Hematology, Johanniter Hospital Bonn, 53113 Bonn, Germany.
Jennifer LandsbergDepartment of Dermatology and Allergy, University Hospital Bonn, 53127 Bonn, Germany.
Felix LehmannDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0003-2847-9271
Alexander RadbruchDepartment of Neuroradiology, University Hospital Bonn, 53127 Bonn, Germany.
Ulrich HerrlingerDivision of Clinical Neuro-Oncology, Department of Neurology, University Hospital Bonn, 53127 Bonn, Germany.
Hartmut VatterDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.
Patrick SchussDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-5806-2576
Matthias SchneiderDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-6025-7479

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurosurgical resection represents an important therapeutic pillar in patients with brain metastasis (BM). Such extended treatment modalities require preoperative assessment of patients' physical status to estimate individual treatment success. The aim of the present study was to analyze the predictive value of frailty and sarcopenia as assessment tools for physiological integrity in patients with non-small cell lung cancer (NSCLC) who had undergone surgery for BM. Between 2013 and 2018, 141 patients were surgically treated for BM from NSCLC at the authors' institution. The preoperative physical condition was assessed by the temporal muscle thickness (TMT) as a surrogate parameter for sarcopenia and the modified frailty index (mFI). For the ≥65 aged group, median overall survival (mOS) significantly differed between patients classified as 'frail' (mFI ≥ 0.27) and 'least and moderately frail' (mFI < 0.27) (15 months versus 11 months (

Indexed as

brain metastasesfrailtynon-small cell lung canceroutcomeoverall survivalsarcopenia

Identifiers

PMID34283079
PMCPMC8267959

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.