Evidence map›Paper›PMID 34283049›Full record

ArticleCancers2021

Comprehensive Somatic Copy Number Analysis Using Aqueous Humor Liquid Biopsy for Retinoblastoma.

Mary E Kim, Ashley Polski, Liya Xu, Rishvanth K Prabakar, Chen-Ching Peng, Mark W Reid, Rachana Shah, Peter Kuhn, David Cobrinik, James Hicks and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Retinoblastoma: Aqueous humor liquid biopsy.Taiwan journal of ophthalmology
    Review
  16. Liquid Biopsy and Ocular Tumors: A Review.Journal of current ophthalmology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mary E KimThe Vision Center at Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.ORCID 0000-0002-7986-6119
Ashley PolskiThe Vision Center at Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.ORCID 0000-0001-6301-6892
Liya XuThe Vision Center at Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Rishvanth K PrabakarDepartment of Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90007, USA.
Chen-Ching PengThe Vision Center at Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Mark W ReidThe Vision Center at Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.ORCID 0000-0002-1942-225X
Rachana ShahCancer and Blood Disease Institute at Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Peter KuhnDepartment of Biological Sciences, Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA 90007, USA.
David CobrinikThe Vision Center at Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
James HicksDepartment of Biological Sciences, Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA 90007, USA.
Jesse L BerryThe Vision Center at Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.ORCID 0000-0002-8907-9100
University of Southern California · USChildren's Hospital of Los Angeles · US

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI William Dean Wallace · 1985 to 2026
$181.4M
Ophthalmic Therapeutics Engineering CoreP30EY029220 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Mahnaz Shahidi · 2018 to 2026
$6.5M
Development of a surrogate liquid biopsy from the aqueous humor in retinoblastoma eyes.K08CA232344 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI BERRY, JESSE L · 2018 to 2022
$1.1M
Carol Vassiliadis Research Fund N/AChildhood Eye Cancer Trust N/AHyundai Hope On Wheels RGA012351Institute for Families, Inc., Children's Hospital Los Angeles N/AKnights Templar Eye Foundation N/ALarry and Celia Moh Foundation N/ANautica Foundation N/ANCI NIH HHS P30CA014089NEI NIH HHS P30 EY029220NIH HHS K08CA232344NIH HHS P30EY029220Research to Prevent Blindness N/AUSC Dornsife College of Letters, Arts and Sciences N/AVicky Joseph Research Fund N/AWright Foundation N/A
6 · The paper itself

Abstract

Aqueous humor (AH) liquid biopsy has been established as a surrogate tumor biopsy for retinoblastoma (RB). Previous AH studies have focused on highly recurrent RB somatic copy number alterations (SCNAs) including gain of 1q, 2p, 6p, and loss of 13q and 16q. In this retrospective study, we provide a comprehensive, whole-genome analysis of RB SCNAs and evaluate associated clinical features for 68 eyes of 64 RB patients from whom AH was obtained between December 2014 and October 2020. Shallow whole-genome sequencing of AH cell-free DNA was performed to assess for SCNAs. The prevalence of specific non-highly recurrent SCNAs, such as 20q gain and 8p loss, differed between primarily and secondarily enucleated eyes. Increases in chromosomal instability predict more advanced seeding morphology (

Indexed as

aqueous humorcell-free DNAcirculating tumor DNAliquid biopsyprecision oncologyprognostic biomarkerretinoblastomaSCNA

Identifiers

PMID34283049
PMCPMC8268955
OpenAlexW3181147003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.