Evidence map›Paper›PMID 34282944›Full record

ArticlemSystems2021

Direct Regulons of AtxA, the Master Virulence Regulator of Bacillus anthracis.

Yoshikazu Furuta, Cheng Cheng, Tuvshinzaya Zorigt, Atmika Paudel, Shun Izumi, Mai Tsujinouchi, Tomoko Shimizu, Wim G Meijer, Hideaki Higashi

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. One Earth: The Equilibrium between the Human and the Bacterial Worlds.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Article
  6. Silkworm model forVirulence · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yoshikazu FurutaDivision of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido Universitygrid.39158.36, Sapporo, Hokkaido, Japan.
Cheng ChengUCD School of Biomolecular and Biomedical Science, University College Dublingrid.7886.1, Dublin, Ireland.
Tuvshinzaya ZorigtDivision of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido Universitygrid.39158.36, Sapporo, Hokkaido, Japan.
Atmika PaudelDivision of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido Universitygrid.39158.36, Sapporo, Hokkaido, Japan.
Shun IzumiDivision of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido Universitygrid.39158.36, Sapporo, Hokkaido, Japan.
Mai TsujinouchiDivision of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido Universitygrid.39158.36, Sapporo, Hokkaido, Japan.
Tomoko ShimizuDivision of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido Universitygrid.39158.36, Sapporo, Hokkaido, Japan.
Wim G MeijerUCD School of Biomolecular and Biomedical Science, University College Dublingrid.7886.1, Dublin, Ireland.
Hideaki HigashiDivision of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido Universitygrid.39158.36, Sapporo, Hokkaido, Japan.
Hokkaido University · JPUniversity College Dublin · IEHealth Sciences University of Hokkaido · JP

Funding

Ministry of Education, Culture, Sports, Science and Technology (MEXT) 18K14672Ministry of Education, Culture, Sports, Science and Technology (MEXT) 18K19436
6 · The paper itself

Abstract

AtxA, the master virulence regulator of Bacillus anthracis, regulates the expression of three toxins and genes for capsule formation that are required for the pathogenicity of B. anthracis. Recent transcriptome analyses showed that AtxA affects a large number of genes on the chromosome and plasmids, suggesting a role as a global regulator. However, information on genes directly regulated by AtxA is scarce. In this work, we conducted genome-wide analyses and cataloged the binding sites of AtxA

Indexed as

Bacillus anthracisCappable-seqChIP-seqDNA-binding proteinssmall RNAtranscriptional regulationtranscription factorsvirulence factors

Identifiers

PMID34282944
PMCPMC8407390
OpenAlexW3183484449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.