ArticlemSystems2021
Antibiotics Shift the Temperature Response Curve of Escherichia coli Growth.
Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Thermal Shifts Dominate Single-Gene Responses to Transcription-Targeting Antibiotics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Climate change and antimicrobial resistance.Nature reviews. Microbiology · 2026Review
- One Health and antimicrobial stewardship: a call to multi-sectoral collaboration to prevent the emerging epidemic of antimicrobial resistance.npj health systems · 2026Article
- Article
- A flexible model for thermal performance curves.Ecology · 2026Article
- Spatial panel data analysis of antimicrobial resistance in Escherichia coli in China.Scientific reports · 2025Article
- Panel data analysis of the effect of ambient temperature on antimicrobial resistance in China.Scientific reports · 2025Article
- Warming is Associated With More Encoded Antimicrobial Resistance Genes and Transcriptions Within Five Drug Classes in Soil Bacteria: A Case Study and Synthesis.Environmental microbiology · 2025Article
- The impact of scale and frass recirculation on pathogen inactivation dynamics in black soldier fly larvae bioconversion.Frontiers in microbiology · 2025Article
- Effect of temperature on the activity of efflux pumps in selected species of human opportunistic bacterial pathogens.Memorias do Instituto Oswaldo Cruz · 2025Article
- No universal mathematical model for thermal performance curves across traits and taxonomic groups.Nature communications · 2024Article
- Temperature dependence of the mutation rate towards antibiotic resistance.JAC-antimicrobial resistance · 2024Article
- Relevance of the Adjuvant Effect between Cellular Homeostasis and Resistance to Antibiotics in Gram-Negative Bacteria with Pathogenic Capacity: A Study ofAntibiotics (Basel, Switzerland) · 2024Review
- Evolution Under Thermal Stress AffectsbioRxiv : the preprint server for biology · 2024Article
- Secondary messenger signalling influences Pseudomonas aeruginosa adaptation to sinus and lung environments.The ISME journal · 2024Article
- Cultivating antimicrobial resistance: how intensive agriculture ploughs the way for antibiotic resistance.Microbiology (Reading, England) · 2023Review
- Association between antibiotic resistance and increasing ambient temperature in China: An ecological study with nationwide panel data.The Lancet regional health. Western Pacific · 2023Article
- It More than Adds Up: Interaction of Antibiotic Mixing and Temperature.Life (Basel, Switzerland) · 2021Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Temperature variation-through time and across climatic gradients-affects individuals, populations, and communities. Yet how the thermal response of biological systems is altered by environmental stressors is poorly understood. Here, we quantify two key features-optimal temperature and temperature breadth-to investigate how temperature responses vary in the presence of antibiotics. We use high-throughput screening to measure growth of Escherichia coli under single and pairwise combinations of 12 antibiotics across seven temperatures that range from 22°C to 46°C. We find that antibiotic stress often results in considerable changes in the optimal temperature for growth and a narrower temperature breadth. The direction of the optimal temperature shifts can be explained by the similarities between antibiotic-induced and temperature-induced damage to the physiology of the bacterium. We also find that the effects of pairs of stressors in the temperature response can often be explained by just one antibiotic out of the pair. Our study has implications for a general understanding of how ecological systems adapt and evolve to environmental changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.