Evidence map›Paper›PMID 34282850›Full record

ArticleHistology and histopathology2021

Primary undifferentiated pleomorphic sarcoma in oral-maxillary area: retrospective study and molecular analysis.

Yuanhe You, Rongxin Shi, Meilu Dai, Zhong Du, Zhuowei Tian, Guisong Xu, Lizhen Wang, Yan'an Wang, Meng Xiao

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Article in Histology and histopathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Multifaceted Roles of Guanylate-Binding Proteins in Cancer.International journal of molecular sciences · 2025
    Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuanhe You *National Clinical Research Center for Oral Disease, Shanghai, China.
Rongxin Shi *Department of Stomatology, Tengzhou Central People's Hospital, Tengzhou, Shandong Province, China.
Meilu DaiDepartment of Orthodontics and Oral Biomedical Engineering Laboratory, Shanghai Stomatological Hospital, Fudan University, Shanghai, China.
Zhong DuNational Clinical Research Center for Oral Disease, Shanghai, China.
Zhuowei TianNational Clinical Research Center for Oral Disease, Shanghai, China.
Guisong XuNational Clinical Research Center for Oral Disease, Shanghai, China.
Lizhen WangNational Clinical Research Center for Oral Disease, Shanghai, China.
Yan'an WangNational Clinical Research Center for Oral Disease, Shanghai, China.
Meng XiaoNational Clinical Research Center for Oral Disease, Shanghai, China.

Funding

National Natural Science Foundation of China 31900947National Natural Science Foundation of China 81870780National Natural Science Foundation of China 81902746Shanghai Sailing Program 19YF1426800
6 · The paper itself

Abstract

Undifferentiated pleomorphic sarcoma (UPS) in oral-maxillary area is rarely reported. Herein, we aimed to investigate the clinical characteristics, treatment strategies, prognosis, and molecular features of the oral-maxillary UPS. In total, 10 cases with primary oral-maxillary UPS were included. The rapidly progressive UPS can easily develop to an advanced and life-threatening stage, especially concerning the complex anatomical structures and spaces in the oral-maxillary area. The final diagnosis for UPS greatly depended on histological findings and immunohistochemistry staining after the exclusion of all possible differential diagnoses. Retrospectively, the treatment strategies for the included cases still referred to those of oral squamous cell carcinoma (OSCC). Statistically, the median overall survival (OS) for all the included cases was 7.75 months (range: 5-17 months). Comparatively, 3 cases had improved OS (median survival: 17 months, range: 17-18 months) and experienced PR/SD with neoadjuvant chemotherapy (anlotinib). The molecular features were demonstrated by using whole exonic sequencing for 1 included case. Cancer driver gene detection revealed GBP4 as a candidate driver gene for the primary oral-maxillary UPS. Additionally, a missense mutation in gene PIK3CA (p.E545K) was also identified. Our findings could greatly expand the knowledge about primary oral-maxillary UPS, and provide molecular evidences to improve the therapeutic options for primary oral-maxillary UPS.

Indexed as

AdultAgedExome SequencingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMouth NeoplasmsRetrospective StudiesSarcomaTomography, X-Ray ComputedYoung Adult

Identifiers

PMID34282850

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.