Evidence map›Paper›PMID 34282777›Full record

ArticleCancers2021

Major Oncogenic Drivers and Their Clinicopathological Correlations in Sporadic Childhood Papillary Thyroid Carcinoma in Belarus.

Tatiana I Rogounovitch, Svetlana V Mankovskaya, Mikhail V Fridman, Tatiana A Leonova, Victor A Kondratovitch, Natalya E Konoplya, Shunichi Yamashita, Norisato Mitsutake, Vladimir A Saenko

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Pathology oncology research : POR · 2023
    Article
  8. Clinicopathological Implications of theFrontiers in medicine · 2022
    Article
  9. TheCancers · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Tatiana I RogounovitchDepartment of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, Japan.
Svetlana V MankovskayaInstitute of Physiology of the National Academy of Sciences of Belarus, 220072 Minsk, Belarus.
Mikhail V FridmanRepublican Centre for Thyroid Tumors, Department of Pathology, Minsk City Clinical Oncologic Dispensary, 220013 Minsk, Belarus.
Tatiana A LeonovaCounseling-Diagnostic Department of Thyroid Diseases, Minsk City Clinical Oncologic Dispensary, 220013 Minsk, Belarus.
Victor A KondratovitchMinsk City Clinical Oncologic Dispensary, 220013 Minsk, Belarus.
Natalya E KonoplyaN.N.Alexandrov National Cancer Centre of Belarus, Department of Chemotherapy, 223040 Minsk, Belarus.
Shunichi YamashitaRadiation Medical Science Center, Fukushima Medical University, Fukushima 960-1295, Japan.
Norisato MitsutakeDepartment of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0000-0002-2744-8046
Vladimir A SaenkoDepartment of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0000-0003-2844-3121
9th City Clinical Hospital · BYNagasaki University · JPFukushima Medical University · JPInstitute of Physiology National Academy of Sciences of Belarus · BYN.N. Alexandrov National Cancer Centre · BY

Funding

Atomic Bomb Disease Institute, Nagasaki University IntramuralBelarusian Republican Foundation for Fundamental Research Б08МС-007Japan Society for the Promotion of Science 19KK02670001
6 · The paper itself

Abstract

Childhood papillary thyroid carcinoma (PTC) diagnosed after the Chernobyl accident in Belarus displayed a high frequency of gene rearrangements and low frequency of point mutations. Since 2001, only sporadic thyroid cancer occurs in children aged up to 14 years but its molecular characteristics have not been reported. Here, we determine the major oncogenic events in PTC from non-exposed Belarusian children and assess their clinicopathological correlations. Among the 34 tumors, 23 (67.6%) harbored one of the mutually exclusive oncogenes: 5 (14.7%)

Indexed as

Chernobylclinicopathological characteristicsgene rearrangementmutationpapillary thyroid carcinomasporadic childhood thyroid cancer

Identifiers

PMID34282777
PMCPMC8268670
OpenAlexW3181800631

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.