Evidence map›Paper›PMID 34282753›Full record

ReviewCancers2021

Current Advances in Basic and Translational Research of Cholangiocarcinoma.

Keisaku Sato, Leonardo Baiocchi, Lindsey Kennedy, Wenjun Zhang, Burcin Ekser, Shannon Glaser, Heather Francis, Gianfranco Alpini

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. The Functional Roles of Immune Cells in Primary Liver Cancer.The American journal of pathology · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Keisaku SatoDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-5380-8001
Leonardo BaiocchiHepatology Unit, Department of Medicine, University of Tor Vergata, 00133 Rome, Italy.
Lindsey KennedyDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Wenjun ZhangDivision of Transplant Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Burcin EkserDivision of Transplant Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Shannon GlaserDepartment of Medical Physiology, Texas A&M University College of Medicine, Bryan, TX 77807, USA.
Heather FrancisDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Gianfranco AlpiniDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Indiana University School of MedicineRichard L. Roudebush VA Medical Center · USTexas A&M University · USUniversity of Rome Tor Vergata · IT

Funding

Mechanisms of mast cell/cholangiocyte regulation of non-alcoholic fatty liver disease progressionR01DK119421 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI FRANCIS, HEATHER L · 2019 to 2022
$1.4M
Mechanisms of synergistic regulation of biliary inflammation and fibrosisI01BX003031 · VA · RLR VA MEDICAL CENTER · PI FRANCIS, HEATHER L · 2016 to 2023
–
BLR&D Research Career Scientist AwardIK6BX004601 · VA · RLR VA MEDICAL CENTER · PI ALPINI, GIANFRANCO D · 2019 to 2025
–
BLR&D Research Career Scientist AwardIK6BX005226 · VA · RLR VA MEDICAL CENTER · PI FRANCIS, HEATHER L · 2020 to 2024
–
BLRD VA I01 BX000574BLRD VA I01 BX003031BLRD VA IK6 BX004601BLRD VA IK6 BX005226NIDDK NIH HHS R01 DK119421NIH HHS DK108959, DK119421, DK054811, DK115184, DK076898, DK107310, DK110035, DK062975, AA028711U.S. Department of Veterans Affairs 5I01BX000574, 1I01BX003031
6 · The paper itself

Abstract

Cholangiocarcinoma (CCA) is a type of biliary tract cancer emerging from the biliary tree. CCA is the second most common primary liver cancer after hepatocellular carcinoma and is highly aggressive resulting in poor prognosis and patient survival. Treatment options for CCA patients are limited since early diagnosis is challenging, and the efficacy of chemotherapy or radiotherapy is also limited because CCA is a heterogeneous malignancy. Basic research is important for CCA to establish novel diagnostic testing and more effective therapies. Previous studies have introduced new techniques and methodologies for animal models, in vitro models, and biomarkers. Recent experimental strategies include patient-derived xenograft, syngeneic mouse models, and CCA organoids to mimic heterogeneous CCA characteristics of each patient or three-dimensional cellular architecture in vitro. Recent studies have identified various novel CCA biomarkers, especially non-coding RNAs that were associated with poor prognosis or metastases in CCA patients. This review summarizes current advances and limitations in basic and translational studies of CCA.

Indexed as

biomarkerscholangiocarcinomagenetic aberrationsorganoidspatient-derived xenograft

Identifiers

PMID34282753
PMCPMC8269372
OpenAlexW3175090969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.