Evidence map›Paper›PMID 34282725›Full record

ArticleeLife2021

An actin-related protein that is most highly expressed in

Courtney M Schroeder, Sarah A Tomlin, Isabel Mejia Natividad, John R Valenzuela, Janet M Young, Harmit S Malik

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Rapid protamine evolution suppresses meiotic drive inbioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Courtney M SchroederDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States.ORCID 0000-0002-4526-8321
Sarah A TomlinDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States.
Isabel Mejia NatividadDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States.
John R ValenzuelaDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States.
Janet M YoungDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States.ORCID 0000-0001-8220-8427
Harmit S MalikDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, United States.ORCID 0000-0001-6005-0016
Fred Hutch Cancer Center · USHoward Hughes Medical Institute · US

Funding

Genetic Conflict Shapes Centromeres and HeterochromatinR01GM074108 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MALIK, HARMIT S. · 2005 to 2022
$6.1M
Genetic Innovation of Cytoskeletal Proteins for Specialized Functions in the Male GermlineK99GM137038 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SCHROEDER, COURTNEY MEGAN · 2020 to 2021
$200k
Howard Hughes Medical InstituteNIGMS NIH HHS K99 GM137038NIGMS NIH HHS R01 GM074108
6 · The paper itself

Abstract

Most actin-related proteins (Arps) are highly conserved and carry out well-defined cellular functions in eukaryotes. However, many lineages like

Indexed as

Embryonic DevelopmentActinsAnimalsDrosophilaDrosophila ProteinsFemaleMaleOvaryTestisActinsArp53D protein, DrosophilaDrosophila Proteinsactincell biologycytoskeletondevelopmentD. melanogasterDrosophilaevolutionfertilitygeneticsgenomics

Identifiers

PMID34282725
PMCPMC8291977
OpenAlexW3187021874

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.