ArticleMethods of information in medicine2021
Why Is the Electronic Health Record So Challenging for Research and Clinical Care?
Article in Methods of information in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Artificial intelligence in personalized computed tomography dose optimization: a systematic review of techniques and clinical outcomes.Frontiers in medicine · 2026Pooled it
- Choosing real-world data for clinical and epidemiological research: methodological lessons from NHIRD and TriNetX-A narrative review.Annals of medicine · 2026Review
- Global, multilingual, physician-invited, patient-completed digital registry enabling pre-consultation engagement and supporting more efficient care pathways in venous disease.Scientific reports · 2026Observational
- Measuring the Impact of Data Quality and Computable Phenotypes on Potential Racial Disparities in Predicting Healthcare Utilization Among Type 2 Diabetes Populations.Journal of racial and ethnic health disparities · 2026Article
- Evaluating the feasibility of health care databases for assessing the safety of switching between originator biologics and biosimilars.Journal of managed care & specialty pharmacy · 2026Article
- Mapping TriNetX-Based Real-World Evidence Publications by Clinical Domain and Study Purpose, 2018-2025: A Bibliometric Analysis.Healthcare (Basel, Switzerland) · 2026Review
- Harmonizing HIV-1 RNA laboratory measurements in a longitudinal cohort collaboration.American journal of epidemiology · 2026Article
- Exploring Technological Solutions for Interoperability Between Patient Electronic Medical Records and Clinical Registries: Scoping Review.Journal of medical Internet research · 2026Article
- Agentic AI and the rise of in silico team science in biomedical research.Nature biotechnology · 2026Review
- Clinical Model Autophagy: The Risk of Interpretative Drift in Recursive Medical AI.JMIR medical informatics · 2026Article
- Can Psychiatric Genetics Advance Without Incorporating a Life Course Perspective?Biological psychiatry · 2026Review
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- Orchestrating the Development of a Sustainable Network IT Solution for a Research Network: Qualitative Participatory Multimethod Design.JMIR formative research · 2026Article
- Predicting Procedure Time in Pediatric Dental Rehabilitation Under General Anesthesia: The Role of Preoperative Factors and Age-Based Models.Paediatric anaesthesia · 2026Article
- Development and Assessment of a Pipeline for Extracting Structured Data From Free-Text Medical Reports Using a Large Language Model.JCO clinical cancer informatics · 2026Article
- Article
- Development and application of the vaccine reporting quality score to evaluate the vaccine adverse event reporting system.Frontiers in immunology · 2026Article
- Integrating medical imaging datasets with blockchain wallets: A case study on ARDS-COVID19 patients.PloS one · 2026Article
- Multinational Pediatric Critical Care Research in the Arab Gulf Region across 35 Pediatric Intensive Care Units: Ethical Approval Timelines and Lessons Learned.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Article
- Assessment of the integrity of real-time electronic health record data used in clinical research.PloS one · 2026Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Funding
Abstract
backgroundThe electronic health record (EHR) has become increasingly ubiquitous. At the same time, health professionals have been turning to this resource for access to data that is needed for the delivery of health care and for clinical research. There is little doubt that the EHR has made both of these functions easier than earlier days when we relied on paper-based clinical records. Coupled with modern database and data warehouse systems, high-speed networks, and the ability to share clinical data with others are large number of challenges that arguably limit the optimal use of the EHR
objectivesOur goal was to provide an exhaustive reference for those who use the EHR in clinical and research contexts, but also for health information systems professionals as they design, implement, and maintain EHR systems.
methodsThis study includes a panel of 24 biomedical informatics researchers, information technology professionals, and clinicians, all of whom have extensive experience in design, implementation, and maintenance of EHR systems, or in using the EHR as clinicians or researchers. All members of the panel are affiliated with Penn Medicine at the University of Pennsylvania and have experience with a variety of different EHR platforms and systems and how they have evolved over time.
resultsEach of the authors has shared their knowledge and experience in using the EHR in a suite of 20 short essays, each representing a specific challenge and classified according to a functional hierarchy of interlocking facets such as usability and usefulness, data quality, standards, governance, data integration, clinical care, and clinical research.
conclusionWe provide here a set of perspectives on the challenges posed by the EHR to clinical and research users.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.