Evidence map›Paper›PMID 34282579›Full record

Trial reportEndoscopy2022

Magnets and a self-retractable wire for endoscopic septotomies: from concept to first-in-human use.

François Huberland, Ricardo Rio-Tinto, Nicolas Cauche, Sonia Dugardeyn, Cécilia Delattre, Charlotte Sandersen, Laureen Rocq, Pauline van Ouytsel, Alain Delchambre, Jacques Devière and 1 more

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

François HuberlandBio, Electro and Mechanical Systems Department, Université Libre de Bruxelles, Brussels, Belgium.ORCID 0000-0002-4258-0803
Ricardo Rio-TintoChampalimaud Foundation, Lisbon, Portugal.
Nicolas CaucheBrussels Medical Device Center, Brussels, Belgium.
Sonia DugardeynDepartment of Gastroenterology, Hepatopancreatology, and Digestive Oncology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Cécilia DelattreBrussels Medical Device Center, Brussels, Belgium.
Charlotte SandersenDepartment of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
Laureen RocqDepartment of Pathology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Pauline van OuytselDepartment of Gastroenterology, Hepatopancreatology, and Digestive Oncology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Alain DelchambreBio, Electro and Mechanical Systems Department, Université Libre de Bruxelles, Brussels, Belgium.
Jacques DevièreChampalimaud Foundation, Lisbon, Portugal.
Daniel BleroDepartment of Gastroenterology, Hepatopancreatology, and Digestive Oncology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Université Libre de Bruxelles · BEChampalimaud Foundation · PTUniversity of Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA medical device that allows simple and safe performance of an endoscopic septotomy could have several applications in the gastrointestinal (GI) tract. We have developed such a device by combining two magnets and a self-retractable wire to perform a progressive septotomy by compression of the tissues. We describe here the concept, preclinical studies, and first clinical use of the device for the treatment of symptomatic epiphrenic esophageal diverticulum (EED).

methodsThe MAGUS (MAgnetic Gastrointestinal Universal Septotome) device was designed based on previous knowledge of compression anastomosis and currently unmet needs. After initial design, the feasibility of the technique was tested on artificial septa in pigs. A clinical trial was then initiated to assess the feasibility and safety of the technique.

resultsAnimal studies showed that the MAGUS can perform a complete septotomy at various levels of the GI tract. In two patients with a symptomatic EED, uneventful complete septotomy was observed within 28 and 39 days after the endoscopic procedure.

conclusionsThis new system provides a way of performing endoluminal septotomy in a single procedure. It appears to be effective and safe for managing symptomatic EED. Further clinical applications where this type of remodeling of the GI tract could be beneficial are under investigation.

Indexed as

Diverticulum, EsophagealMagnetsAnastomosis, SurgicalAnimalsEndoscopyHumansSwineTreatment Outcome

Identifiers

PMID34282579
PMCPMC9132732
OpenAlexW3183738759

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.