Evidence map›Paper›PMID 34282575›Full record

ArticleAmerican journal of perinatology2021

Risk of Cesarean Delivery for Women with Obesity Using a Standardized Labor Induction Protocol.

Rebecca F Hamm, Christina P Teefey, Cara D Dolin, Celeste P Durnwald, Sindhu K Srinivas, Lisa D Levine

Open access · bronzeAbstract read
In one paragraph

Article in American journal of perinatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Cardiovascular-Related Maternal Mortality.Obstetrics and gynecology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Body mass index and failed induction of labor: A cohort study.Acta obstetricia et gynecologica Scandinavica · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rebecca F HammDepartment of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Christina P TeefeyCenter for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Cara D DolinDepartment of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Celeste P DurnwaldDepartment of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Sindhu K SrinivasDepartment of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Lisa D LevineDepartment of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
University of Pennsylvania · USChildren's Hospital of Philadelphia · US

Funding

REPRODUCTIVE EPIDEMIOLOGY TRAINING GRANTT32HD007440 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI BARNHART, KURT T · 1996 to 2020
$7.5M
WOMENS REPRODUCTIVE HEALTH RESEARCH CAREER DEVELOPMENTK12HD001265 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth A Howell · 1998 to 2026
$7.5M
A standardized labor induction protocol to reduce primary cesarean and racial disparities in labor outcomes: a prospective cohort studyK23HD102523 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI HAMM, REBECCA FELDMAN · 2020 to 2023
$680k
NICHD NIH HHS K12 HD001265NICHD NIH HHS K23 HD102523NICHD NIH HHS T32 HD007440
6 · The paper itself

Abstract

objectiveWe aimed to determine the risk of cesarean among women with obesity undergoing labor induction within a prospective trial that utilized a standardized labor protocol. STUDY

designThis was a secondary analysis of a randomized trial of induction methods. Term (≥37 weeks) women with intact membranes undergoing induction with an unfavorable cervix (Bishop's score ≤6 and dilation ≤2 cm) were included. The trial utilized a labor protocol that standardized induction and active labor management, with recommendations for interventions at particular time points. Only women with a recorded body mass index (BMI) at prenatal care start were included in this analysis. The primary outcome was cesarean delivery compared between obese (≥30 kg/m

resultsA total of 465 women were included: 207 (44.5%) obese and 258 (55.5%) nonobese. Women with obesity had a higher risk of cesarean compared with women without obesity (33.3 vs. 23.3%,

conclusionCompared with women without obesity, women with obesity undergoing an induction are at increased risk of cesarean, in particular a failed induction, even within the context of standardized induction management. As standardized practices limit provider variation in labor management, this study may support physiologic differences in labor processes secondary to obesity. KEY POINTS: · Even with a standardized induction protocol, women with obesity are at higher risk of cesarean.. · In particular, women with obesity are at increased risk of cesarean for failed induction.. · These findings support a possible biologic relationship between obesity and failed induction..

Indexed as

Labor, InducedObesityPregnancy ComplicationsAdultBody Mass IndexCesarean SectionFemaleHumansPregnancyProspective StudiesRisk Factors

Identifiers

PMID34282575
PMCPMC9108751
OpenAlexW3185671464

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.