Evidence map›Paper›PMID 34282541›Full record

SynthesisJournal of cardiovascular translational research2022

Venoarterial Extracorporeal Membrane Oxygenation for Acute Massive Pulmonary Embolism: a Meta-Analysis and Call to Action.

Elona Rrapo Kaso, Jonathan A Pan, Michael Salerno, Alexandra Kadl, Chad Aldridge, Ziv J Haskal, Jamie L W Kennedy, Sula Mazimba, Andrew D Mihalek, Nicholas R Teman and 3 more

Open access · bronzeAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of cardiovascular translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Venous thromboembolism following lung transplantation.World journal of transplantation · 2025
    Review
  6. Review
  7. Novel Therapies for Right Ventricular Failure.Current cardiology reports · 2025
    Review
  8. Review
  9. Role of Extracorporeal Membrane Oxygenation in the Treatment of Massive Pulmonary Embolism.The International journal of angiology : official publication of the International College of Angiology, Inc · 2024
    Review
  10. Review
  11. Review
  12. Current status of ECMO for massive pulmonary embolism.Frontiers in cardiovascular medicine · 2023
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Elona Rrapo KasoDepartment of Medicine, Cardiovascular Division, University of Virginia, 1215 Lee Street, Charlottesville, VA, USA.
Jonathan A PanDepartment of Medicine, Cardiovascular Division, University of Virginia, 1215 Lee Street, Charlottesville, VA, USA.
Michael SalernoDepartment of Medicine, Cardiovascular Division, University of Virginia, 1215 Lee Street, Charlottesville, VA, USA.
Alexandra KadlDepartment of Medicine, Division of Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, USA.
Chad AldridgeDepartment of Therapy Services, University of Virginia, Charlottesville, VA, USA.
Ziv J HaskalDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA.
Jamie L W KennedyDivision of Cardiology, Inova Heart and Vascular Institute, Falls Church, VA, USA.
Sula MazimbaDepartment of Medicine, Cardiovascular Division, University of Virginia, 1215 Lee Street, Charlottesville, VA, USA.
Andrew D MihalekDepartment of Medicine, Division of Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, USA.
Nicholas R TemanDepartment of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, VA, USA.
Jay GiriDivision of Cardiology, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Herbert D AronowDepartment of Internal Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Aditya M SharmaDepartment of Medicine, Cardiovascular Division, University of Virginia, 1215 Lee Street, Charlottesville, VA, USA. asharma@virginia.edu.ORCID 0000-0003-1756-2504
University of Virginia · USAlaska Heart and Vascular Institute · USBrown University · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Venoarterial extracorporeal membrane oxygenation (ECMO) has been used to treat acute massive pulmonary embolism (PE) patients. However, the incremental benefit of ECMO to standard therapy remains unclear. Our meta-analysis objective is to compare in-hospital mortality in patients treated for acute massive PE with and without ECMO. The National Library of Medicine MEDLINE (USA), Web of Science, and PubMed databases from inception through October 2020 were searched. Screening identified 1002 published articles. Eleven eligible studies were identified, and 791 patients with acute massive PE were included, of whom 270 received ECMO and 521 did not. In-hospital mortality was not significantly different between patients treated with vs. without ECMO (OR = 1.24 [95% CI, 0.63-2.44], p = 0.54). However, these findings were limited by significant study heterogeneity. Additional research will be needed to clarify the role of ECMO in massive PE treatment. In-hospital mortality for patients with acute massive pulmonary embolism was not significantly different (OR of 1.24, p = 0.54) between those treated with and without venoarterial ECMO.

Indexed as

Extracorporeal Membrane OxygenationPulmonary EmbolismHospital MortalityHumansRetrospective StudiesMassive or high-risk pulmonary embolismVenoarterial extracorporeal membrane oxygenation

Identifiers

PMID34282541
PMCPMC8288068
OpenAlexW3185729884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.