ArticleJournal of cardiovascular translational research2022
Mapping Renal Innervations by Renal Nerve Stimulation and Characterizations of Blood Pressure Response Patterns.
Article in Journal of cardiovascular translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Overcoming variable response in renal denervation: Key strategies for reliable clinical implementation.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Central nervous system mechanisms of salt-sensitive hypertension.Physiological reviews · 2025Review
- Effects of renal denervation at BP-elevation/reduction sites guided by renal nerve stimulation on atrial neural and structural remodeling in a hypertensive canine model.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Aorticorenal ganglion ablation for blood pressure lowering in canine models.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Low-level neurostimulation of the renal nerves as a potential therapeutic strategy for hypertension treatment.Frontiers in pharmacology · 2025Article
- Differences in the effectiveness and safety of different renal denervation devices.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Optogenetics supports to identify the function of renal autonomic system.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Autonomic control of ventricular function in health and disease: current state of the art.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Review
- Emerging topics on renal denervation in hypertension: anatomical and functional aspects of renal nerves.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Renal nerve stimulation identifies renal innervation and optimizes the strategy for renal denervation in canine.Journal of translational medicine · 2023Article
- The role of renal nerve stimulation in percutaneous renal denervation for hypertension: A mini-review.Journal of clinical hypertension (Greenwich, Conn.) · 2022Review
- Best Paper of the Year 2021.Journal of cardiovascular translational research · 2022Article
- Beyond the Anatomy of Renal Nerves: Functional Diversity of Renal Nerves.Journal of cardiovascular translational research · 2022Article
- Present Evidence of Determinants to Predict the Efficacy of Renal Denervation.International journal of hypertension · 2022Review
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased sympathetic nervous activity is one of main contributors to pathogenesis and progression of hypertension. Renal denervation (RDN) has been demonstrated as a potential therapy for treatment of hypertension; however, lack of indicators of intra-/post-procedure results in inconsistent clinical outcomes. Renal nerve stimulation (RNS), a simple and promising method, could evoke elevated blood pressure as an intraoperative indicator for RDN. But related researches on patterns of blood pressure responses to RNS are still incomplete. To investigate and categorize the phenotypes of blood pressure response to RNS and heart rate alteration before and after RNS, 24 Chinese Kunming dogs were used to perform RNS from bifurcation to ostium of renal arteries after angiography, and a total of 483 stimulated sites were complete. We identified five different patterns of blood pressure response to RNS in 483 stimulated sites, (1) continuous ascending and finally keeping steady above baseline (26.9%), (2) declining and then rising over baseline (11.8%), (3) declining and then rising but below baseline (14.5%), (4) fluctuating in the vicinity of baseline (39.5%), and (5) continuous declining and finally keeping steady below baseline (7.2%), and found no difference in RR intervals among five blood pressure responses before and after renal nerve stimulation. Renal nerve stimulation could elicit different patterns of blood pressure response, which could potentially assist in distinguishing sympathetic-excitatory sites and sympathetic-inhibitory sites from mixed nerve components, which might help to improve the efficacy of RDN.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.