Evidence map›Paper›PMID 34282512›Full record

ArticleClinical rheumatology2021

IgA rheumatoid factor is associated with bone mineral density preservation in rheumatoid arthritis.

Rim Sghiri, Asma Boumiza, Hana Benhassine, Nejla Elamri, Zahid Shakoor, Foued Slama, Adel Almogren, Imed Harrabi, Jihen Sahli, Latifa Guaddah and 2 more

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Article in Clinical rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rim SghiriDepartment of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. sghiririm@yahoo.com.
Asma BoumizaLaboratory of Immunology, Research Unit UR 807, Faculty of Medicine of Sousse, Sousse, Tunisia.
Hana BenhassineLaboratory of Immunology, Research Unit UR 807, Faculty of Medicine of Sousse, Sousse, Tunisia.
Nejla ElamriDepartment of Rheumatology, Farhat Hached Hospital, Sousse, Tunisia.
Zahid ShakoorDepartment of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Foued SlamaLaboratory of Immunology, Research Unit UR 807, Faculty of Medicine of Sousse, Sousse, Tunisia.
Adel AlmogrenDepartment of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Imed HarrabiDepartment of Epidemiology, Farhat Hached Hospital, Sousse, Tunisia.
Jihen SahliDepartment of Epidemiology, Farhat Hached Hospital, Sousse, Tunisia.
Latifa GuaddahLaboratory of Immunology, Research Unit UR 807, Faculty of Medicine of Sousse, Sousse, Tunisia.
Hala ZeglaouiDepartment of Rheumatology, Farhat Hached Hospital, Sousse, Tunisia.
Elyes BouajinaDepartment of Rheumatology, Farhat Hached Hospital, Sousse, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAutoantibodies such as IgM rheumatoid factor (RF) and anti-citrullinated proteins/peptides antibodies (ACPA) have previously been incriminated in systemic bone loss in rheumatoid arthritis (RA). There are, however, no data describing association of IgA RF and IgG RF with systemic bone loss.

objectiveThis study was aimed to investigate the association of RF isotypes with systemic bone loss among patients with RA.

methodsRF isotypes and ACPA were measured by enzyme-linked immunosorbent assay among 153 patients with RA. Bone mineral density (BMD) was assessed using dual-energy X-ray absorptiometry.

resultsNinety-four (61.4%) patients had positive IgA RF, 89 (58.2%) had positive IgG RF, 109 (71.2%) had positive IgM RF, whereas 122 (80.3%) RA patients tested positive for ACPA. Compared to the IgA RF-negative patients, IgA RF-positive patients exhibited higher disease activity and had higher RF titers. Seven (4.6%) patients had low BMD at femoral neck, 12 (7.8%) at total femur, and 47 (30.7%) at lumbar spine. IgA RF was found to be associated with protection against low BMD at spine (OR = 0.47, 95% CI = 0.23-0.95, p = 0.034). This association was further confirmed in the multivariate regression analysis taking into account several potential confounding factors (OR = 0.21, 95% CI = 0.06-0.65, p = 0.039). No association between low BMD and the presence of IgG RF or IgM RF or ACPA was found.

conclusionIgA RF for the first time ever was shown to be associated with BMD preservation at spine in RA. Key points • IgA RF was associated with protection against low spinal BMD. • No association between low BMD and the presence of IgG RF or IgM RF was found.

Indexed as

Arthritis, RheumatoidRheumatoid FactorAnti-Citrullinated Protein AntibodiesBone DensityHumansImmunoglobulin AAnti-Citrullinated Protein AntibodiesImmunoglobulin ARheumatoid FactorAnti-cyclic citrullinated proteins/peptides antibodiesBone mineral densityIgA rheumatoid factorIgG rheumatoid factorIgM rheumatoid factorRheumatoid arthritis

Identifiers

PMID34282512

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.