ArticlemedRxiv : the preprint server for health sciences2021
Genetic regulation of
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Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed, 12 citations in OpenAlex.
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Authors and funding
54 authors at 20 institutions in 5 countries.
A Rouf Banday *Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Megan L Stanifer *Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg, Germany.
Oscar Florez-VargasLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Olusegun O OnabajoLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Muhammad A ZahoorToronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Brenen W PapenbergLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Timothy J RingLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Chia-Han LeeLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Evangelos AndreakosLaboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Evgeny AronsLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Greg BarshHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Leslie G BieseckerCenter for Precision Health Research, National Human Genome Research Institute, Bethesda, MD, USA.
David L BoyleAltman Clinical & Translational Research Institute, University of California San Diego Health Sciences, San Diego, CA, USA.
Andrea Burnett-HartmanInstitute for Health Research, Kaiser Permanente Colorado, Aurora, CO, USA.
Mary CarringtonBasic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Euijin ChangDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Pyoeng Gyun ChoeDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Rex L ChrisholmCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Clifton DalgardUniformed Services University of the Health Sciences, Bethesda, MD, USA.
Jeff EdbergDepartment of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Nathan ErdmannDepartment of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.
Heather S FeigelsonInstitute for Health Research, Kaiser Permanente Colorado, Aurora, CO, USA.
Gary S FiresteinAltman Clinical & Translational Research Institute, University of California San Diego Health Sciences, San Diego, CA, USA.
Adam J GehringToronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Michelle HoLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Steven HollandLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Amy A HutchinsonCancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Hogune ImGenome Opinion Inc, Seoul, Republic of Korea.
Michael G IsonDivisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Hong Bin KimDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Robert J KreitmanLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Bruce R KorfDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
Lisa MirabelloClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Jennifer A PachecoCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Michael J PelusoDivision of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, CA, USA.
Daniel J RaderDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
David T ReddenDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Marylyn D RitchieDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Brooke RosenbloomCenter for Precision Health Research, National Human Genome Research Institute, Bethesda, MD, USA.
Hanaisa P Sant AnnaLaboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Sharon SavageClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Eleni SioutiLaboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Vasiliki TriantafylliaLaboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens.
Joselin M VargasLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Anurag VermaDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Vibha VijDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Duane R WesemannDepartment of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Meredith YeagerCancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Xu YuRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Yu ZhangLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Steeve BoulantDivision of Cellular Polarity and Viral Infection, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Jordan J FeldToronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Ludmila Prokunina-OlssonLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
National Cancer Institute · USUniversity of Alabama at Birmingham · USAcademy of Athens · GRNorthwestern University · USSeoul National University · KRUniversity Health Network · CAUniversity of Pennsylvania · USFrederick National Laboratory for Cancer Research · USKaiser Permanente · USNational Human Genome Research Institute · USNational Institute of Allergy and Infectious Diseases · USRagon Institute of MGH, MIT and Harvard · USUniversity of California San Diego · USBrigham and Women's Hospital · USGenome and Company (South Korea) · KRGerman Cancer Research Center · DEHeidelberg University · DEHudsonAlpha Institute for Biotechnology · USUniformed Services University of the Health Sciences · USUniversity of California, San Francisco · US
Funding
National Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6MA Resource for Genetic Epidemiology Research in Adult Health and AgingRC2AG036607 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI RISCH, NEIL J., SCHAEFER, CATHERINE ANN · 2009 to 2010
$24.8MGenomic Ascertainment - Molecular and Genetic AspectsZIAHG200359 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BIESECKER, LESLIE · 2009 to 2025
$19.7MTraining in HIV Translational ResearchT32AI060530 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Diane V Havlir · 2005 to 2026
$6.4MHost Factors in Response to Therapeutic Monoclonal Antibodies and VaccinationU01AI148108 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2020 to 2024
$2.7MPatterns of immune response in COVID-19 patientsZIABC011952 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KREITMAN, ROBERT · 2020 to 2025
$1.6MHost genetic resistance to COVID-19ZIABC011949 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CARRINGTON, MARY N. · 2020 to 2025
$997kCCR NIH HHS HHSN261200800001CNCATS NIH HHS UL1 TR003096NCI NIH HHS HHSN261200800001ENIAID NIH HHS T32 AI060530NIAID NIH HHS U01 AI148108NIA NIH HHS RC2 AG036607
Abstract
Genomic regions have been associated with COVID-19 susceptibility and outcomes, including the chr12q24.13 locus encoding antiviral proteins OAS1-3. Here, we report genetic, functional, and clinical insights into genetic associations within this locus. In Europeans, the risk of hospitalized vs. non-hospitalized COVID-19 was associated with a single 19Kb-haplotype comprised of 76
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.