Evidence map›Paper›PMID 34282376›Full record

ArticleClinical kidney journal2021

Immunosuppression minimization in kidney transplant recipients hospitalized for COVID-19.

Paula Anton Pampols, Hernando Trujillo, Edoardo Melilli, Blanca Urban, Justo Sandino, Alexandre Favá, Eduardo Gutierrez, Oriol Bestard, Esther Mancebo, Angel Sevillano and 2 more

Open access · goldAbstract read
In one paragraph

Article in Clinical kidney journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Occurrence ofKidney international reports · 2022
    Article
  10. Article
  11. Article
  12. Review
  13. Recovery of kidney function after AKI because of COVID-19 in kidney transplant recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2021
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Paula Anton PampolsDepartment of Nephrology, IDIBELL, Bellvitge University Hospital, Barcelona, Spain.
Hernando TrujilloDepartment of Nephrology, University Hospital "12 de Octubre", Madrid, Spain.ORCID 0000-0002-3520-1422
Edoardo MelilliDepartment of Nephrology, IDIBELL, Bellvitge University Hospital, Barcelona, Spain.ORCID 0000-0001-6965-3745
Blanca UrbanDepartment of Immunology, Bellvitge University Hospital, Barcelona, Spain.
Justo SandinoDepartment of Nephrology, University Hospital "12 de Octubre", Madrid, Spain.ORCID 0000-0003-3238-9615
Alexandre FaváDepartment of Nephrology, IDIBELL, Bellvitge University Hospital, Barcelona, Spain.
Eduardo GutierrezDepartment of Nephrology, University Hospital "12 de Octubre", Madrid, Spain.
Oriol BestardDepartment of Nephrology, IDIBELL, Bellvitge University Hospital, Barcelona, Spain.ORCID 0000-0001-9468-7920
Esther ManceboDepartment of Immunology, University Hospital "12 de Octubre", Madrid, Spain.
Angel SevillanoDepartment of Nephrology, University Hospital "12 de Octubre", Madrid, Spain.
Josep M CruzadoDepartment of Nephrology, IDIBELL, Bellvitge University Hospital, Barcelona, Spain.
Enrique MoralesDepartment of Nephrology, University Hospital "12 de Octubre", Madrid, Spain.ORCID 0000-0002-5824-6973
Bellvitge University Hospital · ESResearch Institute Hospital 12 de Octubre · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmunosuppressed patients such as kidney transplant recipients (KTs) have increased mortality risk in the setting of coronavirus disease 2019 (COVID-19). The role and management of chronic immunosuppressive therapies during COVID-19 must be characterized.

methodsHerein, we report the follow-up of a cohort of 47 KTs admitted at two Spanish Kidney Transplant Units, who survived COVID-19. The impact of the management of immunosuppression during COVID-19 on graft function and immunologic events was evaluated.

resultsAt least one immunosuppressive agent was withdrawn in 83% of patients, with antimetabolites being the most frequent. Steroids were generally not stopped and the dose was even increased in 15% of patients as part of the treatment of COVID-19. Although immunosuppressive drugs were suspended during a median time of 17 days, no rejection episodes or

conclusionsOur observational study suggests that immunosuppression in KTs hospitalized due to COVID-19 could be safely minimized.

Indexed as

acute kidney injuryallograft rejectioncoronavirus disease 2019donor-specific antibodiesimmunosuppressionkidney transplantation

Identifiers

PMID34282376
PMCPMC7929031
OpenAlexW3127850463

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.