ArticleNature metabolism2021
Transcriptional regulation of N
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
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- METTL4 regulates synaptic UCP2 N6-adenosine methylation to mediate pain hypersensitivity in female mice.Cellular and molecular life sciences : CMLS · 2025Article
- From Detection to Prediction: Advances in m6A Methylation Analysis Through Machine Learning and Deep Learning with Implications in Cancer.International journal of molecular sciences · 2025Review
- mCell · 2025Article
- Disparities, trends, and projections of cancer mortality burden related to high body mass index in China from 2005 to 2030.Cell reports. Medicine · 2025Article
- METTL14-Induced MAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Association between the combination of the triglyceride-glucose index and obesity-related indices with hyperuricemia among children and adolescents in China.Lipids in health and disease · 2025Article
- Liver-specific actions of GH and IGF1 that protect against MASLD.Nature reviews. Endocrinology · 2025 · on this mapReview
- Sub-Chronic Methomyl Exposure Induces Oxidative Stress and Inflammatory Responses in Zebrafish with Higher Female Susceptibility.Antioxidants (Basel, Switzerland) · 2024Article
- Sex-based differences in short- and longer-term diet-induced metabolic heart disease.American journal of physiology. Heart and circulatory physiology · 2024Article
- Sex differences in energy metabolism: natural selection, mechanisms and consequences.Nature reviews. Nephrology · 2024Review
- The regulatory role of mFrontiers in physiology · 2024Review
- Development of hepatic steatosis in male and female mule ducks after respective force-feeding programs.Frontiers in physiology · 2024Article
- Article
- The impact of chromosomal sex on cardiometabolic health and disease.Trends in endocrinology and metabolism: TEM · 2023Review
- Sexual Dimorphism in Brain Sirtuin-1 and m6A Methylated Sirtuin-1 mRNA, and in Protection with Post-Injury Anti-miR-200c treatment, after Experimental Stroke in Aged Mice.Aging and disease · 2023Article
- mNature metabolism · 2023Article
- Spenito-dependent metabolic sexual dimorphism intrinsic to fat storage cells.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
15 authors at 4 institutions in 2 countries.
David A SalisburyDivision of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
David CaseroF. Widjaja Foundation Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-7347-3330
Zhengyi ZhangDivision of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Dan WangDivision of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Jason KimDivision of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Xiaohui WuDivision of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Laurent VergnesDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Aashiq H MirzaDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Paola Leon-MimilaDivision of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-6334-1492
Kevin J WilliamsDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Adriana Huertas-VazquezDivision of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Samie R JaffreyDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Karen ReueMolecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-7487-2624
Jianjun ChenDepartment of Systems Biology, The Beckman Research Institute of City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0003-3749-2902
Tamer SallamDivision of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. tsallam@mednet.ucla.edu.ORCID http://orcid.org/0000-0001-7144-7393
University of California, Los Angeles · USCornell University · USCedars-Sinai Medical Center · USCity of Hope · US
Funding
CANCER PHARMACOLOGYT32CA062948 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LORRAINE J GUDAS · 1994 to 2026
$12.1MNew mechanisms and technologies for understanding post-transcriptional gene regulation in neuronsR35NS111631 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAMIE R JAFFREY · 2019 to 2026
$8.6MMechanisms of epitranscriptomic regulation in cancerR01CA186702 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAMIE R JAFFREY, Michael Kharas · 2014 to 2026
$8.0MSex Differences in the Metabolic SyndromeU54DK120342 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 2018 to 2022
$7.6MRNA-binding proteins in atherosclerosisR01HL139549 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Tamer Sallam · 2018 to 2026
$3.3MTargeting FTO to treat acute myeloid leukemiaR01CA243386 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, JIANJUN · 2020 to 2024
$2.8MRNA modification in cardiometabolic diseaseR01DK127232 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SALLAM, TAMER · 2021 to 2025
$2.8MLicensing LncRNAs in AtherosclerosisR01HL149766 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SALLAM, TAMER · 2021 to 2024
$2.5MThe role and mechanism of METTL3/METTL14-mediated RNA modification in the pathogenesis and drug-resistance of AMLR01CA236399 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, JIANJUN · 2019 to 2023
$2.3MThe role and mechanism of FTO in leukemogenesis and drug responseR01CA214965 · NCI · UNIVERSITY OF CINCINNATI · PI CHEN, JIANJUN · 2017 to 2021
$2.1MLong Non-coding RNAs in the Regulation of Adipogenesis and ObesityR01DK118086 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SALLAM, TAMER · 2018 to 2022
$1.9MNCI NIH HHS R01 CA186702NCI NIH HHS R01 CA214965NCI NIH HHS R01 CA236399NCI NIH HHS R01 CA243386NCI NIH HHS T32 CA062948NHLBI NIH HHS R01 HL139549NHLBI NIH HHS R01 HL149766NIDDK NIH HHS R01 DK118086NIDDK NIH HHS R01 DK127232NIDDK NIH HHS U54 DK120342NINDS NIH HHS R35 NS111631
Abstract
Males and females exhibit striking differences in the prevalence of metabolic traits including hepatic steatosis, a key driver of cardiometabolic morbidity and mortality. RNA methylation is a widespread regulatory mechanism of transcript turnover. Here, we show that presence of the RNA modification N
Indexed as
Energy MetabolismGene Expression RegulationQuantitative Trait, HeritableTranscription, GeneticAdenosineAnimalsFemaleLipid MetabolismMaleMethylationMiceProto-Oncogene Proteins c-bcl-6Sex FactorsSignal TransductionSTAT5 Transcription FactorAdenosineBcl6 protein, mouseN-methyladenosineProto-Oncogene Proteins c-bcl-6STAT5 Transcription Factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.