Evidence map›Paper›PMID 34282275›Full record

ArticleScientific reports2021

Extracellular detection of neuronal coupling.

Elmer Guzman, Zhuowei Cheng, Paul K Hansma, Kenneth R Tovar, Linda R Petzold, Kenneth S Kosik

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. An integratediScience · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elmer Guzman *Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA.
Zhuowei Cheng *Department of Computer Science, University of California, Santa Barbara, Santa Barbara, CA, USA.
Paul K HansmaDepartment of Physics, University of California, Santa Barbara, Santa Barbara, CA, USA.
Kenneth R TovarNeuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA, USA.
Linda R PetzoldDepartment of Computer Science, University of California, Santa Barbara, Santa Barbara, CA, USA.
Kenneth S KosikDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA. kenneth.kosik@lifesci.ucsb.edu.

Funding

Project 3: Autophagy dysfunction and neuronal activity in FTDU54NS100717 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GAN, LI · 2016 to 2020
$10.8M
NIH grant U54 U54 NS100717-04NINDS NIH HHS U54 NS100717
6 · The paper itself

Abstract

We developed a method to non-invasively detect synaptic relationships among neurons from in vitro networks. Our method uses microelectrode arrays on which neurons are cultured and from which propagation of extracellular action potentials (eAPs) in single axons are recorded at multiple electrodes. Detecting eAP propagation bypasses ambiguity introduced by spike sorting. Our methods identify short latency spiking relationships between neurons with properties expected of synaptically coupled neurons, namely they were recapitulated by direct stimulation and were sensitive to changing the number of active synaptic sites. Our methods enabled us to assemble a functional subset of neuronal connectivity in our cultures.

Indexed as

Action PotentialsAlgorithmsAnimalsAnimals, NewbornCells, CulturedElectrophysiologyExtracellular SpaceMaleMiceMice, Inbred C57BLMicroelectrodesNeuronsSynapsesSynaptic Potentials

Identifiers

PMID34282275
PMCPMC8289866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.