Evidence map›Paper›PMID 34282255›Full record

ArticleScientific reports2021

Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability.

Shiv Bolan, Balaji Seshadri, Simon Keely, Anitha Kunhikrishnan, Jessica Bruce, Ian Grainge, Nicholas J Talley, Ravi Naidu

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Review
  3. The release of absorbed cadmium and lead by probiotic bacteria during in vitro gastrointestinal digestion: a matrix-dependent process.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Integrating experimental data and mechanistic modeling to assess potential lead exposure from tampon use.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  8. Review
  9. Review
  10. Review
  11. The Aging Gut-Brain Axis: Effects of Dietary Polyphenols and Metal Exposure.Chronic diseases and translational medicine · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Neuroprotective effect of engineeredBioengineering & translational medicine · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Shiv BolanGlobal Centre for Environmental Remediation, University of Newcastle, Callaghan, NSW, Australia.
Balaji SeshadriGlobal Centre for Environmental Remediation, University of Newcastle, Callaghan, NSW, Australia.
Simon KeelyHunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Anitha KunhikrishnanGlobal Centre for Environmental Remediation, University of Newcastle, Callaghan, NSW, Australia.
Jessica BruceHunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Ian GraingeSchool of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW, Australia.
Nicholas J TalleyHunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Ravi NaiduGlobal Centre for Environmental Remediation, University of Newcastle, Callaghan, NSW, Australia. Ravi.Naidu@newcastle.edu.au.
University of Newcastle Australia · AUHunter Medical Research Institute · AUCooperative Research Centre for Contamination Assessment and Remediation of the Environment

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, the intestinal permeability of metal(loid)s (MLs) such as arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) was examined, as influenced by gut microbes and chelating agents using an in vitro gastrointestinal/Caco-2 cell intestinal epithelium model. The results showed that in the presence of gut microbes or chelating agents, there was a significant decrease in the permeability of MLs (As-7.5%, Cd-6.3%, Pb-7.9% and Hg-8.2%) as measured by apparent permeability coefficient value (P

Indexed as

ArsenicBiological AvailabilityBiological TransportCaco-2 CellsCadmiumGastrointestinal TractHumansIntestinal AbsorptionIntestinal MucosaLeadMercuryMetals, HeavyPermeabilityArsenicCadmiumLeadMercuryMetals, Heavy

Identifiers

PMID34282255
PMCPMC8289861
OpenAlexW3185423458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.