Evidence map›Paper›PMID 34282123›Full record

ArticleCell discovery2021

Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson's disease.

Pingping Wang, Lifen Yao, Meng Luo, Wenyang Zhou, Xiyun Jin, Zhaochun Xu, Shi Yan, Yiqun Li, Chang Xu, Rui Cheng and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Integrated Single-Cell Multi-Omics Analysis Reveals That a CD8International journal of molecular sciences · 2026
    Article
  10. Article
  11. Single-cell sequencing: accurate disease detection.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
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  20. Robust CD4medRxiv : the preprint server for health sciences · 2025
    Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Pingping Wang *School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Lifen Yao *Department of Neurology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Meng LuoSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Wenyang ZhouSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Xiyun JinSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Zhaochun XuSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Shi YanDepartment of Neurology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Yiqun LiSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Chang XuSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Rui ChengSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Yan HuangSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Xiaoyu LinSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Kexin MaSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Huimin CaoSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Hongxin LiuSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Guangfu XueSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Fang HanSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Huan NieSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Qinghua JiangSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China. qhjiang@hit.edu.cn.
Harbin Institute of Technology · CNFirst Affiliated Hospital of Harbin Medical University · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 62072143
6 · The paper itself

Abstract

Given the chronic inflammatory nature of Parkinson's disease (PD), T cell immunity may be important for disease onset. Here, we performed single-cell transcriptome and TCR sequencing, and conducted integrative analyses to decode composition, function and lineage relationship of T cells in the blood and cerebrospinal fluid of PD. Combined expression and TCR-based lineage tracking, we discovered a large population of CD8

Identifiers

PMID34282123
PMCPMC8289849
OpenAlexW3184557575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.