ArticleTranslational psychiatry2021
Reduced cortical thickness of the paracentral lobule in at-risk mental state individuals with poor 1-year functional outcomes.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 28 citations in OpenAlex.
- Physical Activity and Adolescent Brain Structure, Mental Health, and Academic Outcomes.JAMA network open · 2026Article
- The Effects of Antipsychotics on Two Month Cortical Thickness and Two Year Clinical Outcomes Among Populations at Clinical High Risk for Psychosis.Schizophrenia bulletin · 2026Article
- Superficial white matter microstructural impairments correlate with functional alterations and disease severity in early-stage amyotrophic lateral sclerosis.La Radiologia medica · 2026Article
- Genetic Etiology Link to Brain Function Underlying ADHD Symptoms and its Interaction with Sleep Disturbance: An ABCD Study.Neuroscience bulletin · 2025Article
- Alterations of brain white matter network topological properties in overt hypothyroidism.Endocrine connections · 2025Article
- Multiple voxel pattern analysis shows associations between chronic fatigue syndrome and cortical atrophy.Frontiers in neuroscience · 2025Article
- A 10-Year Longitudinal Study of Brain Cortical Thickness in People with First-Episode Psychosis Using Normative Models.Schizophrenia bulletin · 2024Article
- The microsurgical anatomy of the paracentral lobule artery: a cadaveric series.Surgical and radiologic anatomy : SRA · 2024Article
- The neuroscience of itch in relation to transdiagnostic psychological approaches.Scientific reports · 2024Article
- Multi-scale analysis of acupuncture mechanisms for motor and sensory cortex activity based on SEEG data.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Resting heart rate causally affects the brain cortical structure: Mendelian randomization study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Elucidating salient site-specific functional connectivity features and site-invariant biomarkers in schizophrenia via deep neural networks.Scientific reports · 2023Article
- Sleep Traits Causally Affect the Brain Cortical Structure: A Mendelian Randomization Study.Biomedicines · 2023Article
- Editorial: Prognostic imaging biomarkers in psychotic disorders.Frontiers in psychiatry · 2022Article
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Authors and funding
24 authors at 8 institutions in 1 country.
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Abstract
Although widespread cortical thinning centered on the fronto-temporal regions in schizophrenia has been reported, the findings in at-risk mental state (ARMS) patients have been inconsistent. In addition, it remains unclear whether abnormalities of cortical thickness (CT) in ARMS individuals, if present, are related to their functional decline irrespective of future psychosis onset. In this multicenter study in Japan, T1-weighted magnetic resonance imaging was performed at baseline in 107 individuals with ARMS, who were subdivided into resilient (77, good functional outcome) and non-resilient (13, poor functional outcome) groups based on the change in Global Assessment of Functioning scores during 1-year follow-up, and 104 age- and sex-matched healthy controls recruited at four scanning sites. We measured the CT of the entire cortex and performed group comparisons using FreeSurfer software. The relationship between the CT and cognitive functioning was examined in an ARMS subsample (n = 70). ARMS individuals as a whole relative to healthy controls exhibited a significantly reduced CT, predominantly in the fronto-temporal regions, which was partly associated with cognitive impairments, and an increased CT in the left parietal and right occipital regions. Compared with resilient ARMS individuals, non-resilient ARMS individuals exhibited a significantly reduced CT of the right paracentral lobule. These findings suggest that ARMS individuals partly share CT abnormalities with patients with overt schizophrenia, potentially representing general vulnerability to psychopathology, and also support the role of cortical thinning in the paracentral lobule as a predictive biomarker for short-term functional decline in the ARMS population.
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