ArticleProceedings of the National Academy of Sciences of the United States of America2021
Integration of signals from different cortical areas in higher order thalamic neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- The role of transthalamic pathways in perception.Communications biology · 2026Review
- Connectivity between the seizure onset zone and the thalamus correlates with seizure outcomes in thalamic responsive neurostimulation.Epilepsia · 2026Article
- Somatosensory control of thalamic relay neurons is regulated by two distinct layer 6 feedback systems.iScience · 2026Article
- Pathway-Specific Ultrastructure of Thalamocortical Synapses in Mouse Somatosensory Area S2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Beyond Barrels: Diverse Thalamocortical Projection Motifs in the Mouse Ventral Posterior Complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Synaptic integration of somatosensory and motor cortical inputs onto spiny projection neurons of mice caudoputamen.The European journal of neuroscience · 2024Article
- Anatomo-physiological basis and applied techniques of electrical neuromodulation in chronic pain.Journal of anesthesia, analgesia and critical care · 2024Review
- Specific connectivity optimizes learning in thalamocortical loops.Cell reports · 2024Article
- Review
- A mechanism for deviance detection and contextual routing in the thalamus: a review and theoretical proposal.Frontiers in neuroscience · 2024Article
- Targeted V1 comodulation supports task-adaptive sensory decisions.Nature communications · 2023Article
- Beyond trial-and-error: Individualizing therapeutic transcranial neuromodulation for chronic pain.European journal of pain (London, England) · 2023Review
- Causal relationships between migraine and microstructural white matter: a Mendelian randomization study.The journal of headache and pain · 2023Article
- Associations of thalamocortical networks with reduced mindfulness in alcohol use disorder.Frontiers in psychiatry · 2023Article
- Layer 5 of cortex innervates the thalamic reticular nucleus in mice.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Conserved patterns of functional organization between cortex and thalamus in mice.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Neurosymbolic Systems of Perception and Cognition: The Role of Attention.Frontiers in psychology · 2022Article
- Article
- Distinct "driving" versus "modulatory" influences of different visual corticothalamic pathways.Current biology : CB · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Higher order thalamic neurons receive driving inputs from cortical layer 5 and project back to the cortex, reflecting a transthalamic route for corticocortical communication. To determine whether or not individual neurons integrate signals from different cortical populations, we combined electron microscopy "connectomics" in mice with genetic labeling to disambiguate layer 5 synapses from somatosensory and motor cortices to the higher order thalamic posterior medial nucleus. A significant convergence of these inputs was found on 19 of 33 reconstructed thalamic cells, and as a population, the layer 5 synapses were larger and located more proximally on dendrites than were unlabeled synapses. Thus, many or most of these thalamic neurons do not simply relay afferent information but instead integrate signals as disparate in this case as those emanating from sensory and motor cortices. These findings add further depth and complexity to the role of the higher order thalamus in overall cortical functioning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.