Evidence map›Paper›PMID 34281980›Full record

ArticleeNeuro

Arcuate and Preoptic Kisspeptin Neurons Exhibit Differential Projections to Hypothalamic Nuclei and Exert Opposite Postsynaptic Effects on Hypothalamic Paraventricular and Dorsomedial Nuclei in the Female Mouse.

Todd L Stincic, Jian Qiu, Ashley M Connors, Martin J Kelly, Oline K Rønnekleiv

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 38 citations in OpenAlex.

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  15. Optogenetic stimulation of Kiss1Frontiers in endocrinology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Todd L StincicDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR 97239.ORCID 0000-0001-7504-2422
Jian QiuDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR 97239.ORCID 0000-0002-4988-8587
Ashley M ConnorsDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR 97239.ORCID 0000-0002-6560-9015
Martin J KellyDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR 97239.ORCID 0000-0002-8633-2510
Oline K RønnekleivDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR 97239 ronnekle@ohsu.edu.
Oregon Health & Science University · USOregon National Primate Research Center · US

Funding

Sex Differences in the Control of FeedingR01DK068098 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY, RØNNEKLEIV, OLINE KARIN · 2005 to 2024
$7.1M
Ultrastructure and Single Particle Microscopy CoreP30NS061800 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A · 2009 to 2020
$6.6M
Estrogen Modulation of Bursting Activity in GnRH NeuronsR01NS043330 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI RØNNEKLEIV, OLINE KARIN · 2004 to 2019
$5.5M
Crosstalk between Estrogen and Metabolic Hormone Signaling in Kisspeptin NeuronsR56DK068098 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY, RØNNEKLEIV, OLINE KARIN · 2020 to 2020
$262k
NIDDK NIH HHS R01 DK068098NIDDK NIH HHS R56 DK068098NINDS NIH HHS P30 NS061800NINDS NIH HHS R01 NS043330
6 · The paper itself

Abstract

Kisspeptin (Kiss1) neurons provide indispensable excitatory input to gonadotropin-releasing hormone (GnRH) neurons, which is important for the coordinated release of gonadotropins, estrous cyclicity and ovulation. However, Kiss1 neurons also send projections to many other brain regions within and outside the hypothalamus. Two different populations of Kiss1 neurons, one in the arcuate nucleus (Kiss1

Indexed as

Arcuate Nucleus of HypothalamusKisspeptinsAnimalsFemaleHypothalamusHypothalamus, AnteriorMiceNeuronsKisspeptinshomeostasisneural circuitryoptogeneticspreautonomicreproductionviral tract tracing

Identifiers

PMID34281980
PMCPMC8354717
OpenAlexW3186804668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.