Evidence map›Paper›PMID 34281927›Full record

Observational studyBMJ open2021

Competing-risks nomogram for predicting cancer-specific death in upper tract urothelial carcinoma: a population-based analysis.

Chengzhuo Li, Didi Han, Qiao Huang, Fengshuo Xu, Shuai Zheng, Xiang Li, Fanfan Zhao, Xiaojie Feng, Jun Lyu

Abstract readObservational Study
In one paragraph

Observational study in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chengzhuo LiDepartment of Clinical Research, Jinan University First Affiliated Hospital, Guangzhou, Guangdong, China.
Didi HanDepartment of Clinical Research, Jinan University First Affiliated Hospital, Guangzhou, Guangdong, China.
Qiao HuangDepartment of Chemotherapy and Radiation Therapy, Wuhan University Zhongnan Hospital, Wuhan, Hubei, China.
Fengshuo XuDepartment of Clinical Research, Jinan University First Affiliated Hospital, Guangzhou, Guangdong, China.
Shuai ZhengDepartment of Clinical Research, Jinan University First Affiliated Hospital, Guangzhou, Guangdong, China.
Xiang LiXian Jiaotong University, Xi'an, China.
Fanfan ZhaoDepartment of Clinical Research, Jinan University First Affiliated Hospital, Guangzhou, Guangdong, China.
Xiaojie FengDepartment of Clinical Research, Jinan University First Affiliated Hospital, Guangzhou, Guangdong, China.
Jun LyuDepartment of Clinical Research, Jinan University First Affiliated Hospital, Guangzhou, Guangdong, China lyujun2020@jnu.edu.cn.ORCID 0000-0002-2237-8771

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to use a competing-risks model to establish a nomogram to accurately analyse the prognostic factors for upper tract urothelial carcinoma (UTUC) cancer-specific death (CSD).

designRetrospective observational cohort study.

settingThe programme has yielded a database of all patients with cancer in 18 defined geographical regions of the USA.

participantsWe selected patients with UTUC from the latest edition of the Surveillance, Epidemiology, and End Results database from 1975 to 2016. After excluding patients with unknown histological grade, tumour size and lymph node status, 2576 patients were finally selected. PRIMARY AND SECONDARY OUTCOME MEASURES: We used the Fine-Gray proportional subdistribution hazards model for multivariate analysis and compared the results with cause-specific hazards model. We finally constructed a nomogram for 3-year, 5-year and 8-year CSD rates and tested these rates in a validation cohort.

resultsThe proportional subdistribution hazards model showed that sex, tumour size, distant metastasis, surgery status, number of lymph nodes positive (LNP) and lymph nodes ratio (LNR) were independent prognostic factors for CSD. All significant factors associated with CSD were included in the nomogram. The 3-year, 5-year and 8-year concordance indexes were 0.719, 0.702 and 0.692 in the training cohort and 0.701, 0.675 and 0.668 in the validation cohort, respectively.

conclusionsThe competing-risks model showed that sex, tumour size, distant metastasis, surgery status, LNP and LNR were associated with CSD. The nomogram predicts the probability of CSD in patients with UTUC at 3, 5 and 8 years, which may help clinicians in predicting survival probabilities in individual patients.

Indexed as

Carcinoma, Transitional CellUrinary Bladder NeoplasmsHumansNomogramsPrognosisProportional Hazards ModelsRetrospective Studiesepidemiologyurological tumoursurology

Identifiers

PMID34281927
PMCPMC8291317

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.