Evidence map›Paper›PMID 34281771›Full record

ReviewSeminars in cell & developmental biology2022

Circadian NAD(P)(H) cycles in cell metabolism.

Daniel C Levine, Kathryn M Ramsey, Joseph Bass

Open access · hybridAbstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Genes · 2026
    Article
  2. Review
  3. Article
  4. NADAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Article
  6. Rhythmic Dynamics of Stress Granules inInternational journal of molecular sciences · 2025
    Article
  7. Review
  8. Lipid metabolic adaptations during inflammation are controlled by the circadian clock and impaired by light at night.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  9. Review
  10. Circadian clock disruption promotes retinal photoreceptor degeneration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. NAMPT-dependent NADProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Daniel C LevineDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Kathryn M RamseyDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Joseph BassDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: j-bass@northwestern.edu.
Northwestern University · US

Funding

SLOW WAVE SLEEP AND TYPE 2 DIABETES RISK IN AGINGP01AG011412 · NIA · UNIVERSITY OF CHICAGO · PI ZEE, PHYLLIS C. · 1994 to 2021
$31.5M
Integration of Feeding Time and Glucose Metabolism by the Circadian Gene NetworkR01DK090625 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH, LERNER, TALIA NEWCOMBE · 2011 to 2025
$6.9M
PDX-1,A TRANSCRIPTIONAL ACTIVATOR OF THE INSULIN GENER01DK050203 · NIDDK · VANDERBILT UNIVERSITY · PI BASS, JOSEPH, STEIN, ROLAND W · 1995 to 2020
$6.8M
Cross-regulation of Immunometabolism and Circadian Pathways in Obesity PathophysiologyR01DK127800 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH · 2021 to 2025
$2.3M
Interplay of Dietary Lipid and Circadian Dysregulation in Metabolic SyndromeR01DK100814 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH · 2014 to 2018
$2.3M
Bioenergetic Mechanisms Underlying Circadian Dietary InterventionR01AG065988 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH · 2019 to 2023
$2.0M
The Circadian System as a Neuronal Regulator of Feeding Time and Body Weight SetpointR01DK113011 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH · 2018 to 2021
$1.7M
NIA NIH HHS P01 AG011412NIA NIH HHS R01 AG065988NIDDK NIH HHS R01 DK050203NIDDK NIH HHS R01 DK090625NIDDK NIH HHS R01 DK100814NIDDK NIH HHS R01 DK113011NIDDK NIH HHS R01 DK127800
6 · The paper itself

Abstract

Intrinsic circadian clocks are present in all forms of photosensitive life, enabling daily anticipation of the light/dark cycle and separation of energy storage and utilization cycles on a 24-h timescale. The core mechanism underlying circadian rhythmicity involves a cell-autonomous transcription/translation feedback loop that in turn drives rhythmic organismal physiology. In mammals, genetic studies have established that the core clock plays an essential role in maintaining metabolic health through actions within both brain pacemaker neurons and peripheral tissues and that disruption of the clock contributes to disease. Peripheral clocks, in turn, can be entrained by metabolic cues. In this review, we focus on the role of the nucleotide NAD(P)(H) and NAD

Indexed as

Circadian ClocksSirtuinsAnimalsCircadian RhythmMammalsNADNADSirtuinsAgingCircadian clockMetabolismNicotinamide adenine dinucleotide (NAD(+))Sirtuins

Identifiers

PMID34281771
PMCPMC8761220
OpenAlexW3185508435

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.