ArticleBMC medicine2021
Investigating causal relationships between exposome and human longevity: a Mendelian randomization analysis.
Article in BMC medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- A network-based map of the chemical exposome connects molecular interactions to public health.Nature communications · 2026Article
- COVID-19 infection and longevity: an observational and mendelian randomization study.Journal of translational medicine · 2025Observational
- Review
- Physical activity and the risk of developing 8 age-related diseases: epidemiological and Mendelian randomization studies.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2024Article
- Adopting Mechanistic Molecular Biology Approaches in Exposome Research for Causal Understanding.Environmental science & technology · 2024Review
- [New advances in exposomics-analysis methods and research paradigms based on chromatography-mass spectrometry].Se pu = Chinese journal of chromatography · 2024Review
- Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures.GeroScience · 2023Review
- Alzheimer's Disease: Causal Effect between Obesity and APOE Gene Polymorphisms.International journal of molecular sciences · 2023Article
- Mendelian randomization evidence for the causal effects of socio-economic inequality on human longevity among Europeans.Nature human behaviour · 2023Article
- Article
- Mendelian randomization analyses reveal causal relationships between the human microbiome and longevity.Scientific reports · 2023Article
- Mothers of small-bodied children and fathers of vigorous sons live longer.Frontiers in public health · 2023Article
- Sex differences in the association of fasting glucose with HbA1c, and their consequences for mortality: A Mendelian randomization study.EBioMedicine · 2022Article
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundEnvironmental factors are associated with human longevity, but their specificity and causality remain mostly unclear. By integrating the innovative "exposome" concept developed in the field of environmental epidemiology, this study aims to determine the components of exposome causally linked to longevity using Mendelian randomization (MR) approach.
methodsA total of 4587 environmental exposures extracting from 361,194 individuals from the UK biobank, in exogenous and endogenous domains of exposome were assessed. We examined the relationship between each environmental factor and two longevity outcomes (i.e., surviving to the 90th or 99th percentile age) from various cohorts of European ancestry. Significant results after false discovery rates correction underwent validation using an independent exposure dataset.
resultsOut of all the environmental exposures, eight age-related diseases and pathological conditions were causally associated with lower odds of longevity, including coronary atherosclerosis (odds ratio = 0.77, 95% confidence interval [0.70, 0.84], P = 4.2 × 10
conclusionsThe present study supports that some age-related diseases as well as education are causally related to longevity and highlights several new targets for achieving longevity, including management of venous thromboembolism, appropriate intake of sugar, and control of body fat. Our results warrant further studies to elucidate the underlying mechanisms of these reported causal associations.
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