Evidence map›Paper›PMID 34281397›Full record

ArticlemBio2021

Specificity of NifEN and VnfEN for the Assembly of Nitrogenase Active Site Cofactors in Azotobacter vinelandii.

Ana Pérez-González, Emilio Jimenez-Vicente, Jakob Gies-Elterlein, Alvaro Salinero-Lanzarote, Zhi-Yong Yang, Oliver Einsle, Lance C Seefeldt, Dennis R Dean

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Molecular sorting of nitrogenase catalytic cofactors.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. An FeAngewandte Chemie (International ed. in English) · 2022
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Ana Pérez-GonzálezDepartment of Biochemistry, Virginia Techgrid.438526.e, Blacksburg, Virginia, USA.
Emilio Jimenez-VicenteDepartment of Biochemistry, Virginia Techgrid.438526.e, Blacksburg, Virginia, USA.
Jakob Gies-ElterleinInstitute of Biochemistry, Albert-Ludwigs Universität, Freiburg, Germany.
Alvaro Salinero-LanzaroteCentre for Plant Biotechnology and Genomics, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Universidad Politécnica de Madrid (UPM), Madrid, Spain.
Zhi-Yong YangDepartment of Chemistry and Biochemistry, Utah State Universitygrid.53857.3c, Logan, Utah, USA.
Oliver EinsleInstitute of Biochemistry, Albert-Ludwigs Universität, Freiburg, Germany.
Lance C SeefeldtDepartment of Chemistry and Biochemistry, Utah State Universitygrid.53857.3c, Logan, Utah, USA.
Dennis R DeanDepartment of Biochemistry, Virginia Techgrid.438526.e, Blacksburg, Virginia, USA.
Virginia Tech · USUniversity of Freiburg · DEUtah State University · USUniversidad Politécnica de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nitrogen-fixing microbe Azotobacter vinelandii has the ability to produce three genetically distinct, but mechanistically similar, components that catalyze nitrogen fixation. For two of these components, the Mo-dependent and V-dependent components, their corresponding metal-containing active site cofactors, designated FeMo-cofactor and FeV-cofactor, respectively, are preformed on separate molecular scaffolds designated NifEN and VnfEN, respectively. From prior studies, and the present work, it is now established that neither of these scaffolds can replace the other with respect to their

Indexed as

Catalytic DomainAzotobacter vinelandiiBacterial ProteinsBiocatalysisCoenzymesMolybdoferredoxinNitrogenNitrogenaseNitrogen FixationBacterial ProteinsCoenzymesMolybdoferredoxinNitrogenNitrogenaseassemblyFeFe-cofactorFeMo-cofactorFeV-cofactormolybdenumnitrogenasevanadium

Identifiers

PMID34281397
PMCPMC8406325
OpenAlexW3186257491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.