Evidence map›Paper›PMID 34281386›Full record

ArticlemBio2021

Absence of CD28-CTLA4-PD-L1 Costimulatory Molecules Reduces Herpes Simplex Virus 1 Reactivation.

Harry H Matundan, Ujjaldeep Jaggi, Jack Yu, Omid Akbari, Homayon Ghiasi

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Harry H MatundanCenter for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, Los Angeles, California, USA.
Ujjaldeep JaggiCenter for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, Los Angeles, California, USA.
Jack YuCenter for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, Los Angeles, California, USA.
Omid AkbariDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Homayon GhiasiCenter for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, Los Angeles, California, USA.
Cedars-Sinai Medical Center · USUniversity of Southern California · US

Funding

Role of Macrophages in control of Ocular HSVR01EY024649 · NEI · CEDARS-SINAI MEDICAL CENTER · PI HOMAYON GHIASI · 2015 to 2026
$4.1M
Therapeutic control of HSK by CD80R01EY026944 · NEI · CEDARS-SINAI MEDICAL CENTER · PI GHIASI, HOMAYON · 2016 to 2025
$3.9M
Study the link of autophagy dysfunction to allergic and neutrophilic asthma onsetR01HL151493 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID · 2020 to 2024
$3.6M
Ocular HSV: Mechanism of virus reactivationR01EY029160 · NEI · CEDARS-SINAI MEDICAL CENTER · PI HOMAYON GHIASI · 2018 to 2026
$3.4M
Induction of cells and pathways that promote respiratory tolerance in allergic asthmaR01HL144790 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID · 2019 to 2022
$2.6M
NEI NIH HHS R01 EY024649NEI NIH HHS R01 EY026944NEI NIH HHS R01 EY029160NHLBI NIH HHS R01 HL144790NHLBI NIH HHS R01 HL151493
6 · The paper itself

Abstract

We previously reported that herpes simplex virus 1 (HSV-1) ICP22 binds to CD80 and suppresses CD80 expression

Indexed as

AnimalsB7-H1 AntigenCD28 AntigensCTLA-4 AntigenEyeFemaleHerpes SimplexHerpesvirus 1, HumanMaleMiceMice, Inbred BALB CMice, KnockoutTrigeminal GanglionVirus ActivationVirus LatencyVirus ReplicationB7-H1 AntigenCd274 protein, mouseCD28 AntigensCTLA-4 AntigenCtla4 protein, mouseantigen-presenting cellscorneal scarringHSV-1knockoutlatencyocular infectionreactivation

Identifiers

PMID34281386
PMCPMC8406230
OpenAlexW3186327887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.