Evidence map›Paper›PMID 34281292›Full record

ArticleInternational journal of molecular sciences2021

In Search of Effective Anticancer Agents-Novel Sugar Esters Based on Polyhydroxyalkanoate Monomers.

Wojciech Snoch, Dawid Wnuk, Tomasz Witko, Jakub Staroń, Andrzej J Bojarski, Ewelina Jarek, Francisco J Plou, Maciej Guzik

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. A Novel Lipase fromInternational journal of molecular sciences · 2023
    Article
  4. Article
  5. Article
  6. Physicochemical studies of novel sugar fatty acid esters based on (Frontiers in bioengineering and biotechnology · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wojciech SnochJerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, 30-239 Kraków, Poland.ORCID 0000-0003-1039-1458
Dawid WnukDepartment of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland.
Tomasz WitkoJerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, 30-239 Kraków, Poland.ORCID 0000-0002-1451-0306
Jakub StarońMaj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Kraków, Poland.
Andrzej J BojarskiMaj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Kraków, Poland.ORCID 0000-0003-1417-6333
Ewelina JarekJerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, 30-239 Kraków, Poland.ORCID 0000-0002-1491-4458
Francisco J PlouInstituto de Catalisis y Petroleoquimica, CSIC (Spanish National Research Council), Calle de Marie Curie, 2, 28049 Madrid, Spain.ORCID 0000-0003-0831-893X
Maciej GuzikJerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, 30-239 Kraków, Poland.ORCID 0000-0001-7999-6645

Funding

Narodowe Centrum Badań i Rozwoju POWR.03.02.00-00-I013/16Narodowe Centrum Nauki 2015/17/D/ST4/00514
6 · The paper itself

Abstract

Cancer is one of the deadliest illness globally. Searching for new solutions in cancer treatments is essential because commonly used mixed, targeted and personalized therapies are sometimes not sufficient or are too expensive for common patients. Sugar fatty acid esters (SFAEs) are already well-known as promising candidates for an alternative medical tool. The manuscript brings the reader closer to methods of obtaining various SFAEs using combined biological, chemical and enzymatic methods. It presents how modification of SFAE's hydrophobic chains can influence their cytotoxicity against human skin melanoma and prostate cancer cell lines. The compound's cytotoxicity was determined by an MTT assay, which followed an assessment of SFAEs' potential metastatic properties in concentrations below IC

Indexed as

Antineoplastic AgentsCell Line, TumorCell MovementCell ProliferationDrug DiscoveryDrug Screening Assays, AntitumorEstersFemaleHumansIntermediate FilamentsMalePolyhydroxyalkanoatesStructure-Activity RelationshipSugarsAntineoplastic AgentsEstersPolyhydroxyalkanoatesSugarsanticancer agentschemical modificationsfluorinationmelanomapolyhydroxyalkanoatesprostate cancersugar esters

Identifiers

PMID34281292
PMCPMC8268987

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.