Evidence map›Paper›PMID 34281274›Full record

ArticleInternational journal of molecular sciences2021

Ginsenoside Re Protects against Serotonergic Behaviors Evoked by 2,5-Dimethoxy-4-iodo-amphetamine in Mice via Inhibition of PKCδ-Mediated Mitochondrial Dysfunction.

Eun-Joo Shin, Ji Hoon Jeong, Bao-Trong Nguyen, Naveen Sharma, Seung-Yeol Nah, Yoon Hee Chung, Yi Lee, Jae Kyung Byun, Toshitaka Nabeshima, Sung Kwon Ko and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. A Review of the Mechanisms and Risks ofDiseases (Basel, Switzerland) · 2025
    Review
  2. Article
  3. Article
  4. Protein Kinases and Neurodegenerative Diseases.International journal of molecular sciences · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Eun-Joo ShinNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 24341, Korea.
Ji Hoon JeongDepartment of Global Innovative Drugs, Graduate School of Chung-Ang University, College of Medicine, Chung-Ang University, Seoul 06974, Korea.ORCID 0000-0001-8257-403X
Bao-Trong NguyenNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 24341, Korea.
Naveen SharmaNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 24341, Korea.
Seung-Yeol NahGinsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University, Seoul 05029, Korea.
Yoon Hee ChungDepartment of Anatomy, College of Medicine, Chung-Ang University, Seoul 06974, Korea.
Yi LeeDepartment of Industrial Plant Science & Technology, Chungbuk National University, Chungju 28644, Korea.ORCID 0000-0001-7547-6087
Jae Kyung ByunKorea Society of Forest Environmental Research, Namyanju 12106, Korea.
Toshitaka NabeshimaAdvanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Science, Toyoake 470-1192, Japan.
Sung Kwon KoDepartment of Oriental Medical Food and Nutrition, Semyung University, Jecheon 27136, Korea.
Hyoung-Chun KimNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 24341, Korea.ORCID 0000-0003-0420-795X
Kangwon National University · KRChung-Ang University · KRChungbuk National University · KRFujita Health University · JPKonkuk University · KRKorea Forest Service · KRSemyung University · KR

Funding

Korea Food and Drug Administration #19182MFDS410Korea Forest Service 2020203C10-2122-BA01
6 · The paper itself

Abstract

It has been recognized that serotonin 2A receptor (5-HT

Indexed as

AcetophenonesAmphetaminesAnimalsBehavior, AnimalBenzopyransGinsenosidesHypothalamusMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaOxidative StressPiperidinesProtein Kinase C-deltaProtein Kinase Inhibitors4-iodo-2,5-dimethoxyphenylisopropylamineAcetophenonesalpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanolAmphetaminesBenzopyransginsenoside ReGinsenosidesPiperidinesPrkcd protein, mouseProtein Kinase C-deltaProtein Kinase InhibitorsrottlerinSerotoninSerotonin AntagonistsSerotonin Receptor Agonists5-HT2A receptor agonist DOIginsenoside Rehead twitch responsehyperthermiahypothalamusmitochondrial burdenPKCδ knockout miceserotonergic behaviors

Identifiers

PMID34281274
PMCPMC8268959
OpenAlexW3179564313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.