Evidence map›Paper›PMID 34281268›Full record

ArticleInternational journal of molecular sciences2021

Cytokine/Chemokine Release Patterns and Transcriptomic Profiles of LPS/IFNγ-Activated Human Macrophages Differentiated with Heat-Killed

Samer Bazzi, Emale El-Darzi, Tina McDowell, Helmout Modjtahedi, Satvinder Mudan, Marcel Achkar, Charles Akle, Humam Kadara, Georges M Bahr

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Macrophage Polarization: Learning to Manage It.International journal of molecular sciences · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Samer BazziDivision of Biology and Environmental Science, Faculty of Arts and Sciences, University of Balamand, 33 Amioun, Al Kurah 100, Lebanon.
Emale El-DarziDepartment of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand, 33 Amioun, Al Kurah 100, Lebanon.
Tina McDowellDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Helmout ModjtahediSchool of Life Sciences, Pharmacy and Chemistry, Faculty of Science, Engineering and Computing, Kingston University, Kingston upon Thames, Surrey KT1 2EE, UK.ORCID 0000-0002-5509-7415
Satvinder MudanThe London Clinic, 20 Devonshire Pl, London W1G 6BW, UK.
Marcel AchkarClinical Laboratory, Nini Hospital, Tripoli 1434, Lebanon.
Charles AkleThe London Clinic, 20 Devonshire Pl, London W1G 6BW, UK.ORCID 0000-0002-0333-2073
Humam KadaraDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Georges M BahrDepartment of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand, 33 Amioun, Al Kurah 100, Lebanon.
University of Balamand · LBLondon Clinic · GBThe University of Texas MD Anderson Cancer Center · USKingston University · GBNini Hospital · LB

Funding

Immodulon Therapeutics Ltd., UK NA
6 · The paper itself

Abstract

Macrophages (Mφs) are instrumental regulators of the immune response whereby they acquire diverse functional phenotypes following their exposure to microenvironmental cues that govern their differentiation from monocytes and their activation. The complexity and diversity of the mycobacterial cell wall have empowered mycobacteria with potent immunomodulatory capacities. A heat-killed (HK) whole-cell preparation of

Indexed as

Cell DifferentiationChemokinesCytokinesGranulocyte-Macrophage Colony-Stimulating FactorHumansImmunologic FactorsInterferon-gammaIn Vitro TechniquesLipopolysaccharidesMacrophage ActivationMacrophage Colony-Stimulating FactorMacrophagesNontuberculous MycobacteriaTranscriptomeChemokinesCytokinesGranulocyte-Macrophage Colony-Stimulating FactorImmunologic FactorsInterferon-gammaLipopolysaccharidesMacrophage Colony-Stimulating Factorimmunomodulationmacrophage activationmonocyte-derived macrophagesMycobacterium obuenseRNA sequencing

Identifiers

PMID34281268
PMCPMC8268300
OpenAlexW3180324379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.