Evidence map›Paper›PMID 34281239›Full record

ArticleInternational journal of molecular sciences2021

Simona Ferracchiato, Nicola Di-Iacovo, Damiano Scopetti, Danilo Piobbico, Marilena Castelli, Stefania Pieroni, Marco Gargaro, Giorgia Manni, Stefano Brancorsini, Maria Agnese Della-Fazia and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. International journal of molecular sciences · 2024
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Simona FerracchiatoDepartment of Medicine and Surgery, University of Perugia, Piazzale L. Severi 1, 06129 Perugia, Italy.
Nicola Di-IacovoDepartment of Medicine and Surgery, University of Perugia, Piazzale L. Severi 1, 06129 Perugia, Italy.ORCID 0000-0001-5980-8854
Damiano ScopettiDepartment of Medicine and Surgery, University of Perugia, Piazzale L. Severi 1, 06129 Perugia, Italy.
Danilo PiobbicoDepartment of Medicine and Surgery, University of Perugia, Piazzale L. Severi 1, 06129 Perugia, Italy.
Marilena CastelliDepartment of Medicine and Surgery, University of Perugia, Piazzale L. Severi 1, 06129 Perugia, Italy.
Stefania PieroniDepartment of Medicine and Surgery, University of Perugia, Piazzale L. Severi 1, 06129 Perugia, Italy.
Marco GargaroDepartment of Medicine and Surgery, University of Perugia, Piazzale L. Severi 1, 06129 Perugia, Italy.ORCID 0000-0003-0645-9800
Giorgia ManniDepartment of Medicine and Surgery, University of Perugia, Piazzale L. Severi 1, 06129 Perugia, Italy.
Stefano BrancorsiniDepartment of Medicine and Surgery, University of Perugia, Piazzale L. Severi 1, 06129 Perugia, Italy.
Maria Agnese Della-FaziaDepartment of Medicine and Surgery, University of Perugia, Piazzale L. Severi 1, 06129 Perugia, Italy.ORCID 0000-0002-5373-8477
Giuseppe ServilloDepartment of Medicine and Surgery, University of Perugia, Piazzale L. Severi 1, 06129 Perugia, Italy.ORCID 0000-0001-7960-7689
University of Perugia · IT

Funding

Associazione Umbra Contro il Cancro (AUCC) 001_2021Comitato Maria Grazia Frasconi no grant numberFondazione Ricerca Oncologica Menesini (FROM) no grant numberMinistero dell'Istruzione, dell'Università e della Ricerca 20152CB22L_004
6 · The paper itself

Abstract

HOPS is a ubiquitin-like protein implicated in many aspects of cellular function including the regulation of mitotic activity, proliferation, and cellular stress responses. In this study, we focused on the complex relationship between HOPS and the tumor suppressor p53, investigating both transcriptional and non-transcriptional p53 responses. Here, we demonstrated that

Indexed as

ApoptosisDNA RepairHaploinsufficiencyAnimalsDNA DamageFemaleHeterozygoteIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiceTumor Suppressor Protein p53HOPS protein, mouseIntracellular Signaling Peptides and ProteinsMembrane ProteinsTumor Suppressor Protein p53apoptosisDNA-damage responsehaploinsufficiencyheterozygous mouseHops/Tmub1p53

Identifiers

PMID34281239
PMCPMC8269437
OpenAlexW3173447765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.