Evidence map›Paper›PMID 34281230›Full record

ArticleInternational journal of molecular sciences2021

Evaluating the Effects of Subnormothermic Perfusion with AP39 in a Novel Blood-Free Model of Ex Vivo Kidney Preservation and Reperfusion.

Smriti Juriasingani, Ashley Jackson, Max Yulin Zhang, Aushanth Ruthirakanthan, George J Dugbartey, Emrullah Sogutdelen, Max Levine, Moaath Mandurah, Matthew Whiteman, Patrick Luke and 1 more

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Smriti JuriasinganiDepartment of Microbiology and Immunology, Western University, London, ON N6A 5C1, Canada.
Ashley JacksonMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.
Max Yulin ZhangDepartment of Microbiology and Immunology, Western University, London, ON N6A 5C1, Canada.
Aushanth RuthirakanthanMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.
George J DugbarteyMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.
Emrullah SogutdelenDepartment of Urology, Bolu Abant Izzet Baysal University, Bolu 14030, Turkey.ORCID 0000-0002-1454-5672
Max LevineMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.
Moaath MandurahMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.
Matthew WhitemanSt. Luke's Campus, University of Exeter Medical School, Exeter EX1 2HZ, UK.
Patrick LukeMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.
Alp SenerDepartment of Microbiology and Immunology, Western University, London, ON N6A 5C1, Canada.

Funding

Kidney Foundation of Canada 180015Medical Research Council MC_PC_18047Physicians' Services Incorporated Foundation 18-17
6 · The paper itself

Abstract

The use of blood for normothermic and subnormothermic kidney preservation hinders the translation of these approaches and promising therapeutics. This study evaluates whether adding hydrogen sulfide donor AP39 to Hemopure, a blood substitute, during subnormothermic perfusion improves kidney outcomes. After 30 min of renal pedicle clamping, porcine kidneys were treated to 4 h of static cold storage (SCS-4 °C) or subnormothermic perfusion at 21 °C with Hemopure (H-21 °C), Hemopure + 200 nM AP39 (H200nM-21 °C) or Hemopure + 1 µM AP39 (H1µM-21 °C). Then, kidneys were reperfused with Hemopure at 37 °C for 4 h with metabolic support. Perfusate composition, tissue oxygenation, urinalysis and histopathology were analyzed. During preservation, the H200nM-21 °C group exhibited significantly higher urine output than the other groups and significantly higher tissue oxygenation than the H1µM-21 °C group at 1 h and 2h. During reperfusion, the H200nM-21 °C group exhibited significantly higher urine output and lower urine protein than the other groups. Additionally, the H200nM-21 °C group exhibited higher perfusate pO

Indexed as

HemoglobinsKidneyOrganophosphorus CompoundsThionesAnimalsIn Vitro TechniquesOrgan PreservationReperfusionSwineAP39 compoundHBOC 201HemoglobinsOrganophosphorus CompoundsThionesAP39donation after cardiac death (DCD)hydrogen sulfide (H2S)kidney preservationkidney transplantationsubnormothermic

Identifiers

PMID34281230
PMCPMC8268789

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.