Evidence map›Paper›PMID 34281214›Full record

ArticleInternational journal of molecular sciences2021

Early Transcriptional Liver Signatures in Experimental Visceral Leishmaniasis.

Génesis Palacios, Raquel Diaz-Solano, Basilio Valladares, Roberto Dorta-Guerra, Emma Carmelo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Gene Expression Profiling of Classically Activated Macrophages inTropical medicine and infectious disease · 2023
    Article
  2. Article
  3. Editorial: Immunology and immunopathogenesis of human leishmaniasis.Frontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Génesis PalaciosInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUESTPC), Universidad de la Laguna (ULL), Avenida Astrofísico Francisco Sánchez s/n, 38200 La Laguna (Tenerife), Spain.
Raquel Diaz-SolanoInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUESTPC), Universidad de la Laguna (ULL), Avenida Astrofísico Francisco Sánchez s/n, 38200 La Laguna (Tenerife), Spain.
Basilio ValladaresInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUESTPC), Universidad de la Laguna (ULL), Avenida Astrofísico Francisco Sánchez s/n, 38200 La Laguna (Tenerife), Spain.
Roberto Dorta-GuerraInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUESTPC), Universidad de la Laguna (ULL), Avenida Astrofísico Francisco Sánchez s/n, 38200 La Laguna (Tenerife), Spain.ORCID 0000-0002-7269-1889
Emma CarmeloInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUESTPC), Universidad de la Laguna (ULL), Avenida Astrofísico Francisco Sánchez s/n, 38200 La Laguna (Tenerife), Spain.ORCID 0000-0003-1126-993X
Universidad de La Laguna · ES

Funding

Fundación CajaCanarias 2015 BIO14Fundación Canaria para el Control de Enfermedades Tropicales (FUNCCET) nonePrograma de ayudas a la formación del personal investigador para la realización de tesis doctorales en Canarias de la Consejería de Economía, Industria, Comercio y Conocimiento cofinanciada en un 85% por el Fondo Social Europeo", TESIS2019010018Red de Investigación de Centros de Enfermedades Tropicales (RICET)-Ministerio de Economía y Competitividad-Instituto de Salud Carlos III RD16/0027/0001Universidad de La Laguna (ULL) none
6 · The paper itself

Abstract

Transcriptional analysis of complex biological scenarios has been used extensively, even though sometimes the results of such analysis may prove imprecise or difficult to interpret due to an overwhelming amount of information. In this study, a large-scale real-time qPCR experiment was coupled to multivariate statistical analysis in order to describe the main immunological events underlying the early

Indexed as

AnimalsFemaleGene Expression ProfilingInterleukin-12Leishmaniasis, VisceralLipid MetabolismLiverMiceMice, Inbred BALB CTh1 CellsInterleukin-12gene expressiongene signaturehigh-throughput RT-qPCRLeishmania infantumlivermouse experimental modelmultivariate analysisprincipal component analysistranscriptional profiling

Identifiers

PMID34281214
PMCPMC8267970
OpenAlexW3173822049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.